pH clock-operated mechanized nanoparticles

Sarah Angelos; Niveen M. Khashab; Ying Wei Yang; Ali Trabolsi; Hussam A. Khatib; J. Fraser Stoddart; Jeffrey I. Zink

doi:10.1021/ja9010157

pH clock-operated mechanized nanoparticles

Sarah Angelos, Niveen M. Khashab, Ying Wei Yang, Ali Trabolsi, Hussam A. Khatib, J. Fraser Stoddart, Jeffrey I. Zink

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Mechanized nanoparticles (MNPs) consisting of supramolecular machines attached to the surface of mesoporous silica nanoparticles are designed to release encapsulated guest molecules controllably under pH activation. The molecular machines are comprised of cucurbit[6]uril (CB[6]) rings that encircle tethered trisammonium stalks and can be tuned to respond under specific pH conditions through chemical modification of the stalks. Luminescence spectroscopy demonstrates that the MNPs are able to contain guest molecules within nanopores at neutral pH levels and then release them once the pH is lowered or raised.

Original language	English (US)
Pages (from-to)	12912-12914
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	131
Issue number	36
DOIs	https://doi.org/10.1021/ja9010157
State	Published - Sep 16 2009

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja9010157

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title = "pH clock-operated mechanized nanoparticles",

abstract = "Mechanized nanoparticles (MNPs) consisting of supramolecular machines attached to the surface of mesoporous silica nanoparticles are designed to release encapsulated guest molecules controllably under pH activation. The molecular machines are comprised of cucurbit[6]uril (CB[6]) rings that encircle tethered trisammonium stalks and can be tuned to respond under specific pH conditions through chemical modification of the stalks. Luminescence spectroscopy demonstrates that the MNPs are able to contain guest molecules within nanopores at neutral pH levels and then release them once the pH is lowered or raised.",

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AU - Angelos, Sarah

AU - Khashab, Niveen M.

AU - Yang, Ying Wei

AU - Trabolsi, Ali

AU - Khatib, Hussam A.

AU - Stoddart, J. Fraser

AU - Zink, Jeffrey I.

PY - 2009/9/16

Y1 - 2009/9/16

N2 - Mechanized nanoparticles (MNPs) consisting of supramolecular machines attached to the surface of mesoporous silica nanoparticles are designed to release encapsulated guest molecules controllably under pH activation. The molecular machines are comprised of cucurbit[6]uril (CB[6]) rings that encircle tethered trisammonium stalks and can be tuned to respond under specific pH conditions through chemical modification of the stalks. Luminescence spectroscopy demonstrates that the MNPs are able to contain guest molecules within nanopores at neutral pH levels and then release them once the pH is lowered or raised.

AB - Mechanized nanoparticles (MNPs) consisting of supramolecular machines attached to the surface of mesoporous silica nanoparticles are designed to release encapsulated guest molecules controllably under pH activation. The molecular machines are comprised of cucurbit[6]uril (CB[6]) rings that encircle tethered trisammonium stalks and can be tuned to respond under specific pH conditions through chemical modification of the stalks. Luminescence spectroscopy demonstrates that the MNPs are able to contain guest molecules within nanopores at neutral pH levels and then release them once the pH is lowered or raised.

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pH clock-operated mechanized nanoparticles

Abstract

ASJC Scopus subject areas

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