pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

L. Palanikumar; Sumaya Al-Hosani; Mona Kalmouni; Vanessa P. Nguyen; Liaqat Ali; Renu Pasricha; Francisco N. Barrera; Mazin Magzoub

doi:10.1038/s42003-020-0817-4

pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

L. Palanikumar, Sumaya Al-Hosani, Mona Kalmouni, Vanessa P. Nguyen, Liaqat Ali, Renu Pasricha, Francisco N. Barrera, Mazin Magzoub

Research output: Contribution to journal › Article › peer-review

Abstract

The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible and biodegradable pH-responsive hybrid NPs that overcome these issues. The NPs consist of a drug-loaded polylactic-co-glycolic acid (PLGA) core covalently ‘wrapped’ with a crosslinked bovine serum albumin (BSA) shell designed to minimize interactions with serum proteins and macrophages that inhibit target recognition. The shell is functionalized with the acidity-triggered rational membrane (ATRAM) peptide to facilitate internalization specifically into cancer cells within the acidic tumor microenvironment. Following uptake, the unique intracellular conditions of cancer cells degrade the NPs, thereby releasing the chemotherapeutic cargo. The drug-loaded NPs showed potent anticancer activity in vitro and in vivo while exhibiting no toxicity to healthy tissue. Our results demonstrate that the ATRAM-BSA-PLGA NPs are a promising targeted cancer drug delivery platform.

Original language	English (US)
Article number	95
Journal	Communications Biology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1038/s42003-020-0817-4
State	Published - Dec 1 2020

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

Access to Document

10.1038/s42003-020-0817-4

Cite this

@article{56a5a5eff0fc4c49862313373e2354dd,

title = "pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics",

abstract = "The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible and biodegradable pH-responsive hybrid NPs that overcome these issues. The NPs consist of a drug-loaded polylactic-co-glycolic acid (PLGA) core covalently {\textquoteleft}wrapped{\textquoteright} with a crosslinked bovine serum albumin (BSA) shell designed to minimize interactions with serum proteins and macrophages that inhibit target recognition. The shell is functionalized with the acidity-triggered rational membrane (ATRAM) peptide to facilitate internalization specifically into cancer cells within the acidic tumor microenvironment. Following uptake, the unique intracellular conditions of cancer cells degrade the NPs, thereby releasing the chemotherapeutic cargo. The drug-loaded NPs showed potent anticancer activity in vitro and in vivo while exhibiting no toxicity to healthy tissue. Our results demonstrate that the ATRAM-BSA-PLGA NPs are a promising targeted cancer drug delivery platform.",

author = "L. Palanikumar and Sumaya Al-Hosani and Mona Kalmouni and Nguyen, {Vanessa P.} and Liaqat Ali and Renu Pasricha and Barrera, {Francisco N.} and Mazin Magzoub",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s42003-020-0817-4",

language = "English (US)",

volume = "3",

journal = "Communications Biology",

issn = "2399-3642",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

AU - Palanikumar, L.

AU - Al-Hosani, Sumaya

AU - Kalmouni, Mona

AU - Nguyen, Vanessa P.

AU - Ali, Liaqat

AU - Pasricha, Renu

AU - Barrera, Francisco N.

AU - Magzoub, Mazin

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible and biodegradable pH-responsive hybrid NPs that overcome these issues. The NPs consist of a drug-loaded polylactic-co-glycolic acid (PLGA) core covalently ‘wrapped’ with a crosslinked bovine serum albumin (BSA) shell designed to minimize interactions with serum proteins and macrophages that inhibit target recognition. The shell is functionalized with the acidity-triggered rational membrane (ATRAM) peptide to facilitate internalization specifically into cancer cells within the acidic tumor microenvironment. Following uptake, the unique intracellular conditions of cancer cells degrade the NPs, thereby releasing the chemotherapeutic cargo. The drug-loaded NPs showed potent anticancer activity in vitro and in vivo while exhibiting no toxicity to healthy tissue. Our results demonstrate that the ATRAM-BSA-PLGA NPs are a promising targeted cancer drug delivery platform.

AB - The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible and biodegradable pH-responsive hybrid NPs that overcome these issues. The NPs consist of a drug-loaded polylactic-co-glycolic acid (PLGA) core covalently ‘wrapped’ with a crosslinked bovine serum albumin (BSA) shell designed to minimize interactions with serum proteins and macrophages that inhibit target recognition. The shell is functionalized with the acidity-triggered rational membrane (ATRAM) peptide to facilitate internalization specifically into cancer cells within the acidic tumor microenvironment. Following uptake, the unique intracellular conditions of cancer cells degrade the NPs, thereby releasing the chemotherapeutic cargo. The drug-loaded NPs showed potent anticancer activity in vitro and in vivo while exhibiting no toxicity to healthy tissue. Our results demonstrate that the ATRAM-BSA-PLGA NPs are a promising targeted cancer drug delivery platform.

UR - http://www.scopus.com/inward/record.url?scp=85081197725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85081197725&partnerID=8YFLogxK

U2 - 10.1038/s42003-020-0817-4

DO - 10.1038/s42003-020-0817-4

M3 - Article

C2 - 32127636

AN - SCOPUS:85081197725

SN - 2399-3642

VL - 3

JO - Communications Biology

JF - Communications Biology

IS - 1

M1 - 95

ER -

pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this