TY - GEN
T1 - Phase-resolved reflectance spectroscopy on layered turbid media
AU - Hielscher, Andreas H.
AU - Liu, Hanli
AU - Chance, Britton
AU - Tittel, Frank K.
AU - Jacques, Steven L.
N1 - Publisher Copyright:
© 2018 SPIE.
PY - 1995/5/30
Y1 - 1995/5/30
N2 - In this study, we investigate the influence of layered tissue structures on the phase-resolved reflectance. As a particular example, we consider the affect of the skin, skull, and meninges on noninvasive blood oxygenation determination of the brain. In this case, it's important to know how accurate one can measure the absorption coefficient of the brain through the enclosing layers of different tissues. Experiments were performed on layered gelatin tissue phantoms and the results compared to diffusion theory. It is shown that when a high absorbing medium is placed on top of a low absorbing medium, the absorption coefficient of the lower layer is accessible. In the inverse case, where a low absorbing medium is placed on top of a high absorbing medium, the absorption coefficient of the underlying medium can only be determined if the differences in the absorption coefficient are small, or the top layer is very thin. Investigations on almost absorption and scattering free layers, like the cerebral fluid filled arachnoid, reveal that the determination of the absorption coefficient is barely affected by these kinds of structures.
AB - In this study, we investigate the influence of layered tissue structures on the phase-resolved reflectance. As a particular example, we consider the affect of the skin, skull, and meninges on noninvasive blood oxygenation determination of the brain. In this case, it's important to know how accurate one can measure the absorption coefficient of the brain through the enclosing layers of different tissues. Experiments were performed on layered gelatin tissue phantoms and the results compared to diffusion theory. It is shown that when a high absorbing medium is placed on top of a low absorbing medium, the absorption coefficient of the lower layer is accessible. In the inverse case, where a low absorbing medium is placed on top of a high absorbing medium, the absorption coefficient of the underlying medium can only be determined if the differences in the absorption coefficient are small, or the top layer is very thin. Investigations on almost absorption and scattering free layers, like the cerebral fluid filled arachnoid, reveal that the determination of the absorption coefficient is barely affected by these kinds of structures.
UR - http://www.scopus.com/inward/record.url?scp=85010116447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85010116447&partnerID=8YFLogxK
U2 - 10.1117/12.209974
DO - 10.1117/12.209974
M3 - Conference contribution
AN - SCOPUS:85010116447
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 248
EP - 256
BT - Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media
A2 - Chance, Britton
A2 - Alfano, Robert R.
PB - SPIE
T2 - Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation
Y2 - 1 February 1995 through 28 February 1995
ER -