Photochromic blockers of voltage-gated potassium channels

Matthew R. Banghart; Alexandre Mourot; Doris L. Fortin; Jennifer Z. Yao; Richard H. Kramer; Dirk Trauner

doi:10.1002/anie.200904504

Photochromic blockers of voltage-gated potassium channels

Matthew R. Banghart, Alexandre Mourot, Doris L. Fortin, Jennifer Z. Yao, Richard H. Kramer, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Light work: Studies into the mechanism of AAQ, a photoswitchable blocker of voltage-gated K⁺ channels, led to the discovery and development of photochromic ligands that act at the internal tetraethylammonium binding site (see picture). These molecules can be applied from the extracellular side to impart longlasting photosensitivity on K⁺ channels in living cells and thereby afford photocontrol of action potential firing in neurons.

Original language	English (US)
Pages (from-to)	9097-9101
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	48
DOIs	https://doi.org/10.1002/anie.200904504
State	Published - Nov 16 2009

Keywords

Azo compounds
Ion channels
Open-channel block
Photochromism
Structure-activity relationships

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200904504

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abstract = "Light work: Studies into the mechanism of AAQ, a photoswitchable blocker of voltage-gated K+ channels, led to the discovery and development of photochromic ligands that act at the internal tetraethylammonium binding site (see picture). These molecules can be applied from the extracellular side to impart longlasting photosensitivity on K+ channels in living cells and thereby afford photocontrol of action potential firing in neurons.",

keywords = "Azo compounds, Ion channels, Open-channel block, Photochromism, Structure-activity relationships",

author = "Banghart, {Matthew R.} and Alexandre Mourot and Fortin, {Doris L.} and Yao, {Jennifer Z.} and Kramer, {Richard H.} and Dirk Trauner",

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AU - Mourot, Alexandre

AU - Fortin, Doris L.

AU - Yao, Jennifer Z.

AU - Kramer, Richard H.

AU - Trauner, Dirk

PY - 2009/11/16

Y1 - 2009/11/16

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KW - Azo compounds

KW - Ion channels

KW - Open-channel block

KW - Photochromism

KW - Structure-activity relationships

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Photochromic blockers of voltage-gated potassium channels

Abstract

Keywords

ASJC Scopus subject areas

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