Photochromic blockers of voltage-gated potassium channels

Matthew R. Banghart, Alexandre Mourot, Doris L. Fortin, Jennifer Z. Yao, Richard H. Kramer, Dirk Trauner

Research output: Contribution to journalArticlepeer-review


Light work: Studies into the mechanism of AAQ, a photoswitchable blocker of voltage-gated K+ channels, led to the discovery and development of photochromic ligands that act at the internal tetraethylammonium binding site (see picture). These molecules can be applied from the extracellular side to impart longlasting photosensitivity on K+ channels in living cells and thereby afford photocontrol of action potential firing in neurons.

Original languageEnglish (US)
Pages (from-to)9097-9101
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number48
StatePublished - Nov 16 2009


  • Azo compounds
  • Ion channels
  • Open-channel block
  • Photochromism
  • Structure-activity relationships

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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