Photodynamic therapy based on graphene and MXene in cancer theranostics

Arianna Gazzi; Laura Fusco; Anooshay Khan; Davide Bedognetti; Barbara Zavan; Flavia Vitale; Acelya Yilmazer; Lucia Gemma Delogu

doi:10.3389/fbioe.2019.00295

Photodynamic therapy based on graphene and MXene in cancer theranostics

Arianna Gazzi, Laura Fusco, Anooshay Khan, Davide Bedognetti, Barbara Zavan, Flavia Vitale, Acelya Yilmazer, Lucia Gemma Delogu

Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Cancer is one of the leading causes of death in the world. Therefore, the development of new advanced and targeted strategies in cancer research for early diagnosis and treatment has become essential to improve diagnosis outcomes and reduce therapy side effects. Graphene and more recently, MXene, are the main representatives of the family of two-dimensional (2D) materials and are widely studied as multimodal nanoplatforms for cancer diagnostics and treatment, in particular leveraging their potentialities as photodynamic therapeutic agents. Indeed, due to their irreplaceable physicochemical properties, they are virtuous allies for photodynamic therapy (PDT) in combination with bioimaging, photothermal therapy, as well as drug and gene delivery. In this review, the rapidly progressing literature related to the use of these promising 2D materials for cancer theranostics is described in detail, highlighting all their possible future advances in PDT.

Original language	English (US)
Article number	295
Journal	Frontiers in Bioengineering and Biotechnology
Volume	7
Issue number	OCT
DOIs	https://doi.org/10.3389/fbioe.2019.00295
State	Published - 2019

Keywords

Graphene
MXene
Nanomedicine
Photodynamic therapy
Theranostics

ASJC Scopus subject areas

Biotechnology
Bioengineering
Histology
Biomedical Engineering

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10.3389/fbioe.2019.00295

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title = "Photodynamic therapy based on graphene and MXene in cancer theranostics",

abstract = "Cancer is one of the leading causes of death in the world. Therefore, the development of new advanced and targeted strategies in cancer research for early diagnosis and treatment has become essential to improve diagnosis outcomes and reduce therapy side effects. Graphene and more recently, MXene, are the main representatives of the family of two-dimensional (2D) materials and are widely studied as multimodal nanoplatforms for cancer diagnostics and treatment, in particular leveraging their potentialities as photodynamic therapeutic agents. Indeed, due to their irreplaceable physicochemical properties, they are virtuous allies for photodynamic therapy (PDT) in combination with bioimaging, photothermal therapy, as well as drug and gene delivery. In this review, the rapidly progressing literature related to the use of these promising 2D materials for cancer theranostics is described in detail, highlighting all their possible future advances in PDT.",

keywords = "Graphene, MXene, Nanomedicine, Photodynamic therapy, Theranostics",

author = "Arianna Gazzi and Laura Fusco and Anooshay Khan and Davide Bedognetti and Barbara Zavan and Flavia Vitale and Acelya Yilmazer and Delogu, {Lucia Gemma}",

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year = "2019",

doi = "10.3389/fbioe.2019.00295",

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AU - Gazzi, Arianna

AU - Fusco, Laura

AU - Khan, Anooshay

AU - Bedognetti, Davide

AU - Zavan, Barbara

AU - Vitale, Flavia

AU - Yilmazer, Acelya

AU - Delogu, Lucia Gemma

PY - 2019

Y1 - 2019

N2 - Cancer is one of the leading causes of death in the world. Therefore, the development of new advanced and targeted strategies in cancer research for early diagnosis and treatment has become essential to improve diagnosis outcomes and reduce therapy side effects. Graphene and more recently, MXene, are the main representatives of the family of two-dimensional (2D) materials and are widely studied as multimodal nanoplatforms for cancer diagnostics and treatment, in particular leveraging their potentialities as photodynamic therapeutic agents. Indeed, due to their irreplaceable physicochemical properties, they are virtuous allies for photodynamic therapy (PDT) in combination with bioimaging, photothermal therapy, as well as drug and gene delivery. In this review, the rapidly progressing literature related to the use of these promising 2D materials for cancer theranostics is described in detail, highlighting all their possible future advances in PDT.

AB - Cancer is one of the leading causes of death in the world. Therefore, the development of new advanced and targeted strategies in cancer research for early diagnosis and treatment has become essential to improve diagnosis outcomes and reduce therapy side effects. Graphene and more recently, MXene, are the main representatives of the family of two-dimensional (2D) materials and are widely studied as multimodal nanoplatforms for cancer diagnostics and treatment, in particular leveraging their potentialities as photodynamic therapeutic agents. Indeed, due to their irreplaceable physicochemical properties, they are virtuous allies for photodynamic therapy (PDT) in combination with bioimaging, photothermal therapy, as well as drug and gene delivery. In this review, the rapidly progressing literature related to the use of these promising 2D materials for cancer theranostics is described in detail, highlighting all their possible future advances in PDT.

KW - Graphene

KW - MXene

KW - Nanomedicine

KW - Photodynamic therapy

KW - Theranostics

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JF - Frontiers in Bioengineering and Biotechnology

IS - OCT

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Photodynamic therapy based on graphene and MXene in cancer theranostics

Abstract

Keywords

ASJC Scopus subject areas

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