TY - JOUR
T1 - Photopharmacological control of cell signaling with photoswitchable lipids
AU - Mukhopadhyay, Tufan K.
AU - Morstein, Johannes
AU - Trauner, Dirk
N1 - Publisher Copyright:
© 2022
PY - 2022/4
Y1 - 2022/4
N2 - Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their biological applications. These include immunomodulation, kinase translocation, apoptosis, ion channel activation, G-protein coupled receptor activation, and neurogenesis.
AB - Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their biological applications. These include immunomodulation, kinase translocation, apoptosis, ion channel activation, G-protein coupled receptor activation, and neurogenesis.
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U2 - 10.1016/j.coph.2022.102202
DO - 10.1016/j.coph.2022.102202
M3 - Review article
C2 - 35278838
AN - SCOPUS:85125878100
SN - 1471-4892
VL - 63
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
M1 - 102202
ER -