Photoreceptor subtype specification: From flies to humans

Tiffany Cook; Claude Desplan

doi:10.1006/scdb.2001.0275

Photoreceptor subtype specification: From flies to humans

Research output: Contribution to journal › Article › peer-review

Abstract

Multiple cell types often differentiate from a pluripotent cell. These cells may then further diversify as distinct subtypes. The visual system provides an ideal model for studying subtype specification as various photoreceptors acquire different functions based on the type of opsin they express. Opsin expression is mostly controlled through transcriptional mechanisms that are evolutionary conserved from Drosophila to humans. In addition, it appears that, from a 'default' developmental state, distinct 'acquired' photoreceptor states develop upon receiving intrinsic or extrinsic signals. This review discusses factors involved in opsin gene regulation and how their integration may explain how subtype specificity is achieved.

Original language	English (US)
Pages (from-to)	509-518
Number of pages	10
Journal	Seminars in Cell and Developmental Biology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1006/scdb.2001.0275
State	Published - 2001

Keywords

LCR
Opsin
Otd
Photoreceptor
Transcription factors

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1006/scdb.2001.0275

Cite this

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title = "Photoreceptor subtype specification: From flies to humans",

abstract = "Multiple cell types often differentiate from a pluripotent cell. These cells may then further diversify as distinct subtypes. The visual system provides an ideal model for studying subtype specification as various photoreceptors acquire different functions based on the type of opsin they express. Opsin expression is mostly controlled through transcriptional mechanisms that are evolutionary conserved from Drosophila to humans. In addition, it appears that, from a 'default' developmental state, distinct 'acquired' photoreceptor states develop upon receiving intrinsic or extrinsic signals. This review discusses factors involved in opsin gene regulation and how their integration may explain how subtype specificity is achieved.",

keywords = "LCR, Opsin, Otd, Photoreceptor, Transcription factors",

author = "Tiffany Cook and Claude Desplan",

note = "Funding Information: We wish to thank Nadean Brown, Isabelle Brun, Brian Gebelein, Bertrand Mollereau, Maureen Neitz, and Franck Pichaud for their useful comments, suggestions, and discussion of this topic. We also thank Remi Sonneville for the image of the Rh5/Rh6 expression pattern shown in Figure 1. We apologize to those whose work has contributed to our understanding of photoreceptor subtype specification but was not included due to space limitations. TC is supported by an NIH NRSA fellowship. This work was supported by grants from NEI/NIH to CD.",

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doi = "10.1006/scdb.2001.0275",

language = "English (US)",

volume = "12",

pages = "509--518",

journal = "Seminars in Cell and Developmental Biology",

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publisher = "Elsevier Ltd",

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T1 - Photoreceptor subtype specification

T2 - From flies to humans

AU - Cook, Tiffany

AU - Desplan, Claude

N1 - Funding Information: We wish to thank Nadean Brown, Isabelle Brun, Brian Gebelein, Bertrand Mollereau, Maureen Neitz, and Franck Pichaud for their useful comments, suggestions, and discussion of this topic. We also thank Remi Sonneville for the image of the Rh5/Rh6 expression pattern shown in Figure 1. We apologize to those whose work has contributed to our understanding of photoreceptor subtype specification but was not included due to space limitations. TC is supported by an NIH NRSA fellowship. This work was supported by grants from NEI/NIH to CD.

PY - 2001

Y1 - 2001

N2 - Multiple cell types often differentiate from a pluripotent cell. These cells may then further diversify as distinct subtypes. The visual system provides an ideal model for studying subtype specification as various photoreceptors acquire different functions based on the type of opsin they express. Opsin expression is mostly controlled through transcriptional mechanisms that are evolutionary conserved from Drosophila to humans. In addition, it appears that, from a 'default' developmental state, distinct 'acquired' photoreceptor states develop upon receiving intrinsic or extrinsic signals. This review discusses factors involved in opsin gene regulation and how their integration may explain how subtype specificity is achieved.

AB - Multiple cell types often differentiate from a pluripotent cell. These cells may then further diversify as distinct subtypes. The visual system provides an ideal model for studying subtype specification as various photoreceptors acquire different functions based on the type of opsin they express. Opsin expression is mostly controlled through transcriptional mechanisms that are evolutionary conserved from Drosophila to humans. In addition, it appears that, from a 'default' developmental state, distinct 'acquired' photoreceptor states develop upon receiving intrinsic or extrinsic signals. This review discusses factors involved in opsin gene regulation and how their integration may explain how subtype specificity is achieved.

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KW - Opsin

KW - Otd

KW - Photoreceptor

KW - Transcription factors

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Photoreceptor subtype specification: From flies to humans

Abstract

Keywords

ASJC Scopus subject areas

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