Photoreceptor subtype specification: From flies to humans

Tiffany Cook, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Multiple cell types often differentiate from a pluripotent cell. These cells may then further diversify as distinct subtypes. The visual system provides an ideal model for studying subtype specification as various photoreceptors acquire different functions based on the type of opsin they express. Opsin expression is mostly controlled through transcriptional mechanisms that are evolutionary conserved from Drosophila to humans. In addition, it appears that, from a 'default' developmental state, distinct 'acquired' photoreceptor states develop upon receiving intrinsic or extrinsic signals. This review discusses factors involved in opsin gene regulation and how their integration may explain how subtype specificity is achieved.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume12
Issue number6
DOIs
StatePublished - 2001

Keywords

  • LCR
  • Opsin
  • Otd
  • Photoreceptor
  • Transcription factors

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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