Physical and chemical characterization of synthetic bone mineral ink for robocasting applications

Daniel Eckstein, Cristobal Rivera, Dindo Mijares, Paulo G. Coelho, Lukasz Witek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: Yearly, millions of individuals suffer from bone defects caused by trauma or congenital disease1. The “gold standard” is to fill these boney defects with an autologous bone graft, however, issues of availability, morbidity, secondary surgical site and customizability have lead to the use of synthetic grafting modalities2. The novel formulation of Synthetic Bone Mineral (SBM) is a viable option as a synthetic graft material. SBM is a carbonated hydroxyapatite with ionic substitutions of Zinc, chloride, fluoride, and magnesium, which closely mimics the chemistry of biological apatite3. Robocasting technology offers the flexibility in bone graft customization, geometry and composition. Our team has leveraged 3D printing technology to manufacture custom scaffolds using various bioactive ceramic materials without the need for a mold4. The objective of this work was to first synthesize a colloidal gel composed of SBM, then which would be suitable for Robocasting applications and characterize it chemically and mechanically.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Eckstein, D., Rivera, C., Mijares, D., Coelho, P. G., & Witek, L. (2019). Physical and chemical characterization of synthetic bone mineral ink for robocasting applications. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.