Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria

Pia A. Elustondo; Adrienne E. White; Meghan E. Hughes; Karen Brebner; Evgeny Pavlov; Daniel A. Kane

doi:10.1074/jbc.M113.476648

Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria

Pia A. Elustondo, Adrienne E. White, Meghan E. Hughes, Karen Brebner, Evgeny Pavlov, Daniel A. Kane

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The notion of mitochondrial lactate oxidation in skeletal muscle is controversial. Results: Mitochondrial respiration increased in the presence of substrates and cofactors for the lactate dehydrogenase (LDH) reaction. Respiration was inhibited when mitochondrial pyruvate transport was blocked. Conclusion: Extra-matrix LDH is associated with muscle mitochondria. Significance: LDH is strategically positioned within skeletal muscle fibers to functionally interact with mitochondria.

Original language	English (US)
Pages (from-to)	25309-25317
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M113.476648
State	Published - Aug 30 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.476648

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abstract = "Background: The notion of mitochondrial lactate oxidation in skeletal muscle is controversial. Results: Mitochondrial respiration increased in the presence of substrates and cofactors for the lactate dehydrogenase (LDH) reaction. Respiration was inhibited when mitochondrial pyruvate transport was blocked. Conclusion: Extra-matrix LDH is associated with muscle mitochondria. Significance: LDH is strategically positioned within skeletal muscle fibers to functionally interact with mitochondria.",

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AU - White, Adrienne E.

AU - Hughes, Meghan E.

AU - Brebner, Karen

AU - Pavlov, Evgeny

AU - Kane, Daniel A.

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background: The notion of mitochondrial lactate oxidation in skeletal muscle is controversial. Results: Mitochondrial respiration increased in the presence of substrates and cofactors for the lactate dehydrogenase (LDH) reaction. Respiration was inhibited when mitochondrial pyruvate transport was blocked. Conclusion: Extra-matrix LDH is associated with muscle mitochondria. Significance: LDH is strategically positioned within skeletal muscle fibers to functionally interact with mitochondria.

AB - Background: The notion of mitochondrial lactate oxidation in skeletal muscle is controversial. Results: Mitochondrial respiration increased in the presence of substrates and cofactors for the lactate dehydrogenase (LDH) reaction. Respiration was inhibited when mitochondrial pyruvate transport was blocked. Conclusion: Extra-matrix LDH is associated with muscle mitochondria. Significance: LDH is strategically positioned within skeletal muscle fibers to functionally interact with mitochondria.

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Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria

Abstract

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