Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria

Pia A. Elustondo, Adrienne E. White, Meghan E. Hughes, Karen Brebner, Evgeny Pavlov, Daniel A. Kane

Research output: Contribution to journalArticle

Abstract

Background: The notion of mitochondrial lactate oxidation in skeletal muscle is controversial. Results: Mitochondrial respiration increased in the presence of substrates and cofactors for the lactate dehydrogenase (LDH) reaction. Respiration was inhibited when mitochondrial pyruvate transport was blocked. Conclusion: Extra-matrix LDH is associated with muscle mitochondria. Significance: LDH is strategically positioned within skeletal muscle fibers to functionally interact with mitochondria.

Original languageEnglish (US)
Pages (from-to)25309-25317
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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