Physical properties and biodegradation of lactide-based poly(ethylene glycol) polymer networks for tissue engineering

Young Min Ju; Kwang Duk Ahn; Jong Man Kim; Jeffrey A. Hubbell; Dong Keun Han

doi:10.1007/s00289-003-0132-5

Physical properties and biodegradation of lactide-based poly(ethylene glycol) polymer networks for tissue engineering

Young Min Ju, Kwang Duk Ahn, Jong Man Kim, Jeffrey A. Hubbell, Dong Keun Han

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

New lactide-based poly(ethylene glycol) (PEG) polymer networks (GL-PEG) have been prepared by photopolymerization using two nontoxic macromers, triacrylated lactic acid oligomer emanating from a glycerol center (GL) and monoacrylated PEG. These materials may use as polymer scaffolds in tissue engineering because they provide biodegradable, cell-adhesion resistant, and ligand-immobilizable characteristics. The thermal and mechanical properties of the resulting GL-PEG networks were evaluated and their biodegradability was investigated in phosphate buffered saline (PBS) at 80°C. The glass transition temperature (Tg) of all networks after degradation relatively decreased and the trend was similar to those before biodegradation, whereas thermal decomposition temperature (Td_1/2) increased in all networks to a certain degree. The tensile strength decreased as PEG was incorporated and as the molecular weight and content of PEG increased due to the soft PEG chains. Degradation rate of GL-PEG networks was controlled by the ratio of GL to PEG, and generally the rate of GL-PEG networks was faster than that of GL homonetworks.

Original language	English (US)
Pages (from-to)	107-114
Number of pages	8
Journal	Polymer Bulletin
Volume	50
Issue number	1-2
DOIs	https://doi.org/10.1007/s00289-003-0132-5
State	Published - Apr 2003

ASJC Scopus subject areas

General Chemistry
Condensed Matter Physics
Polymers and Plastics
Materials Chemistry

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title = "Physical properties and biodegradation of lactide-based poly(ethylene glycol) polymer networks for tissue engineering",

abstract = "New lactide-based poly(ethylene glycol) (PEG) polymer networks (GL-PEG) have been prepared by photopolymerization using two nontoxic macromers, triacrylated lactic acid oligomer emanating from a glycerol center (GL) and monoacrylated PEG. These materials may use as polymer scaffolds in tissue engineering because they provide biodegradable, cell-adhesion resistant, and ligand-immobilizable characteristics. The thermal and mechanical properties of the resulting GL-PEG networks were evaluated and their biodegradability was investigated in phosphate buffered saline (PBS) at 80°C. The glass transition temperature (Tg) of all networks after degradation relatively decreased and the trend was similar to those before biodegradation, whereas thermal decomposition temperature (Td1/2) increased in all networks to a certain degree. The tensile strength decreased as PEG was incorporated and as the molecular weight and content of PEG increased due to the soft PEG chains. Degradation rate of GL-PEG networks was controlled by the ratio of GL to PEG, and generally the rate of GL-PEG networks was faster than that of GL homonetworks.",

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AU - Ahn, Kwang Duk

AU - Kim, Jong Man

AU - Hubbell, Jeffrey A.

AU - Han, Dong Keun

PY - 2003/4

Y1 - 2003/4

N2 - New lactide-based poly(ethylene glycol) (PEG) polymer networks (GL-PEG) have been prepared by photopolymerization using two nontoxic macromers, triacrylated lactic acid oligomer emanating from a glycerol center (GL) and monoacrylated PEG. These materials may use as polymer scaffolds in tissue engineering because they provide biodegradable, cell-adhesion resistant, and ligand-immobilizable characteristics. The thermal and mechanical properties of the resulting GL-PEG networks were evaluated and their biodegradability was investigated in phosphate buffered saline (PBS) at 80°C. The glass transition temperature (Tg) of all networks after degradation relatively decreased and the trend was similar to those before biodegradation, whereas thermal decomposition temperature (Td1/2) increased in all networks to a certain degree. The tensile strength decreased as PEG was incorporated and as the molecular weight and content of PEG increased due to the soft PEG chains. Degradation rate of GL-PEG networks was controlled by the ratio of GL to PEG, and generally the rate of GL-PEG networks was faster than that of GL homonetworks.

AB - New lactide-based poly(ethylene glycol) (PEG) polymer networks (GL-PEG) have been prepared by photopolymerization using two nontoxic macromers, triacrylated lactic acid oligomer emanating from a glycerol center (GL) and monoacrylated PEG. These materials may use as polymer scaffolds in tissue engineering because they provide biodegradable, cell-adhesion resistant, and ligand-immobilizable characteristics. The thermal and mechanical properties of the resulting GL-PEG networks were evaluated and their biodegradability was investigated in phosphate buffered saline (PBS) at 80°C. The glass transition temperature (Tg) of all networks after degradation relatively decreased and the trend was similar to those before biodegradation, whereas thermal decomposition temperature (Td1/2) increased in all networks to a certain degree. The tensile strength decreased as PEG was incorporated and as the molecular weight and content of PEG increased due to the soft PEG chains. Degradation rate of GL-PEG networks was controlled by the ratio of GL to PEG, and generally the rate of GL-PEG networks was faster than that of GL homonetworks.

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Physical properties and biodegradation of lactide-based poly(ethylene glycol) polymer networks for tissue engineering

Abstract

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