Physico/chemical characterization and preliminary human histology assessment of a β-TCP particulate material for bone augmentation

Paulo G. Coelho, Maria E. Coimbra, Cristiane Ribeiro, Elizabeth Fancio, Olga Higa, Marcelo Suzuki, Mauro Marincola

Research output: Contribution to journalArticlepeer-review


This study aimed to physico/chemically characterize and evaluate the in vivo performance of a β-TCP particulate grafting material. SEM/TEM, and EDS and XPS were used for morphology and chemistry assessment, respectively. FTIR was used to determine Ca-P phases characteristic bands. Rietveld refinement/XRD spectra was performed for secondary phase detection. Particle size distribution and specific surface were assessed by a scattering-laser based technique and BET, respectively. Mercury porosimetry was employed to determine pore-size distribution. For in vivo evaluation, the grafting material was used in 12 patients' sinus lifts, and biopsies were obtained at post-operative times of 3, 6, and 9 months. SEM/TEM revealed multigrained particles with interconnected pores. EDS showed Ca, P, and O, with stoichiometry close to theoretical values. XRD/Rietveld showed that the material presented crystalline β-TCP with ~ 9% β-Ca2P2O7 secondary phase. FTIR did not detect the presence of bands related to α-TCP. Human histologic assessment showed that newly formed bone was present at 3 months, and degrees of bone organization increased as time elapsed in vivo. Human histology showed that the material is suitable for bone regeneration in a maxillofacial complex region.

Original languageEnglish (US)
Pages (from-to)2085-2091
Number of pages7
JournalMaterials Science and Engineering C
Issue number7
StatePublished - Aug 31 2009


  • Biocompatibility
  • Human histology
  • In vitro test
  • Physicho/chemical characterization
  • β-TCP

ASJC Scopus subject areas

  • General Materials Science
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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