Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors

Goichi Miyoshi, Simon J.B. Butt, Hirohide Takebayashi, Gord Fishell

Research output: Contribution to journalArticle

Abstract

Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

Original languageEnglish (US)
Pages (from-to)7786-7798
Number of pages13
JournalJournal of Neuroscience
Volume27
Issue number29
DOIs
StatePublished - Jul 18 2007

Keywords

  • Cortex
  • Electrophysiology
  • GABA
  • Genetics
  • Interneurons
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors'. Together they form a unique fingerprint.

  • Cite this