TY - JOUR
T1 - Pilot study
T2 - digital subtraction radiography as a tool to assess alveolar bone changes in periodontitis patients under treatment with subantimicrobial doses of doxycycline
AU - Goren, Arthur D.
AU - Dunn, Stanley M.
AU - Wolff, Mark
AU - van der Stelt, Paul F.
AU - Colosi, Dan C.
AU - Golub, Lorne M.
PY - 2008/10
Y1 - 2008/10
N2 - Background: Subtle changes in marginal alveolar bone level can be demonstrated using digital subtraction of sequential radiographs. Objective: We aimed to evaluate the practical application of geometrically corrected digital subtraction in a clinical study of alveolar bone response to a drug previously shown to inhibit alveolar bone loss. Study design: Selected periapical radiographs were acquired with projective standardization of patients with clinical marginal alveolar bone loss. Subsequently, patients received a 6-month regimen of subantimicrobial doxycycline or placebo. Standardized radiographs of the same alveolar regions were acquired after 3 and 6 months, and baseline radiographs were subtracted from these images. Results: Blinded digital subtraction analysis indicated various levels of marginal bone gain in 3 of the 6 patients in the experimental group, whereas in 3 of the 5 placebo patients the method showed bone loss. Conclusion: These results suggest that geometrically corrected digital subtraction possibly agrees with clinical predictors of bone loss severity.
AB - Background: Subtle changes in marginal alveolar bone level can be demonstrated using digital subtraction of sequential radiographs. Objective: We aimed to evaluate the practical application of geometrically corrected digital subtraction in a clinical study of alveolar bone response to a drug previously shown to inhibit alveolar bone loss. Study design: Selected periapical radiographs were acquired with projective standardization of patients with clinical marginal alveolar bone loss. Subsequently, patients received a 6-month regimen of subantimicrobial doxycycline or placebo. Standardized radiographs of the same alveolar regions were acquired after 3 and 6 months, and baseline radiographs were subtracted from these images. Results: Blinded digital subtraction analysis indicated various levels of marginal bone gain in 3 of the 6 patients in the experimental group, whereas in 3 of the 5 placebo patients the method showed bone loss. Conclusion: These results suggest that geometrically corrected digital subtraction possibly agrees with clinical predictors of bone loss severity.
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U2 - 10.1016/j.tripleo.2008.06.010
DO - 10.1016/j.tripleo.2008.06.010
M3 - Article
C2 - 18718780
AN - SCOPUS:55049094500
SN - 1079-2104
VL - 106
SP - e40-e45
JO - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
JF - Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
IS - 4
ER -