Pilot study on monitoring ulcer healing with diffuse optical imaging in a patient cohort affected by peripheral arterial disease (PAD)

N. Maheshwari, A. Marone, M. Altoé, H. K. Kim, D. R. Bajakian, A. H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Ulcers are a common occurrence in diabetic patients with peripheral arterial disease (PAD). Early prognosis of ulcer healing can help patients avoid prolonged pain and future amputation by alerting physicians to intervention efficacy. However, monitoring of ulcers and predicting intervention success remains a challenge. We have developed a so-called vascular optical tomography imaging system (VOTIS) to address this problem. The system consists of patches with infrared sources and silicon photodiodes. The patches are placed on areas of interest in the lower extremities and light attenuation data is obtained at multiple frames per second. During data acquisition, a thigh cuff is inflated and deflated to affect blood flow to the lower extremities, resulting in dynamic changes of the recorded signals. Features such as maximum change in total absorption, response time to cuff inflation, and plateau time (PT) between cuff inflation and deflation can be extracted. Here we report on a pilot study of 10 PAD patients (70% diabetic) with ulcers, who had a surgical intervention to improve blood flow. VOTIS measurements were obtained immediately after the intervention, and again three weeks later. Prognosis was determined from EHR and classified as improvement (N=7) - when an ulcer reduces in size - or no improvement (N=3). In an ROC analysis, the VOTIS-derived biomarker PT demonstrated high classification potential (Sn=86%, Sp=100%, AUC=0.95).

    Original languageEnglish (US)
    Title of host publicationOptical Diagnostics and Sensing XXII
    Subtitle of host publicationToward Point-of-Care Diagnostics
    EditorsGerard L. Cote
    PublisherSPIE
    ISBN (Electronic)9781510648074
    DOIs
    StatePublished - 2022
    EventOptical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics 2022 - Virtual, Online
    Duration: Feb 20 2022Feb 24 2022

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume11968
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics 2022
    CityVirtual, Online
    Period2/20/222/24/22

    Keywords

    • Peripheral arterial disease (PAD)
    • point-ofcare monitoring
    • treatment monitoring
    • ulcer healing
    • ulcers
    • wound monitoring

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Atomic and Molecular Physics, and Optics
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

    Fingerprint

    Dive into the research topics of 'Pilot study on monitoring ulcer healing with diffuse optical imaging in a patient cohort affected by peripheral arterial disease (PAD)'. Together they form a unique fingerprint.

    Cite this