@article{5ac7d9ff992f4d7fae0a228a9c661f96,
title = "Pinpointing the neural signatures of single-exposure visual recognition memory",
abstract = "Memories of the images that we have seen are thought to be reflected in the reduction of neural responses in high-level visual areas such as inferotemporal (IT) cortex, a phenomenon known as repetition suppression (RS). We challenged this hypothesis with a task that required rhesus monkeys to report whether images were novel or repeated while ignoring variations in contrast, a stimulus attribute that is also known to modulate the overall IT response. The monkeys' behavior was largely contrast invariant, contrary to the predictions of an RS-inspired decoder, which could not distinguish responses to images that are repeated from those that are of lower contrast. However, the monkeys' behavioral patterns were well predicted by a linearly decodable variant in which the total spike count was corrected for contrast modulation. These results suggest that the IT neural activity pattern that best aligns with single-exposure visual recognition memory behavior is not RS but rather sensory referenced suppression: reductions in IT population response magnitude, corrected for sensory modulation.",
keywords = "Contrast, Familiarity, Population decoding, Recognition memory, Repetition suppression",
author = "Vahid Mehrpour and Travis Meyer and Simoncelli, {Eero P.} and Rust, {Nicole C.}",
note = "Funding Information: ACKNOWLEDGMENTS. Recent work in neuroscience and related fields has identified citation biases whereby work from women and minorities are undercited relative to other papers in the field (34–36). In crafting this manuscript, we sought to proactively consider citation bias. Following ref. 34, the gender balance of citations was quantified based on the first names of the first/last authors using open source code (37). Excluding self-citations, this article contains 58.3% man/man, 16.7% man/woman, 19.4% woman/man, and 5.6% woman/woman citations. For comparison, proportions estimated from articles in the five top neuroscience journals (as reported in ref. 34) are 58.4% man/man, 9.4% man/woman, 25.5% woman/man, and 6.7% woman/woman. This work was supported by the Simons Foundation (Simons Collaboration on the Global Brain award 543033 to N.C.R. and 543047 to E.P.S.), the National Eye Institute of the NIH (award R01EY020851 to N.C.R.), the NSF (CAREER award 1265480 to N.C.R.), and the Howard Hughes Medical Institute (investigatorship to E.P.S.). Publisher Copyright: {\textcopyright} 2021 National Academy of Sciences. All rights reserved.",
year = "2021",
month = may,
day = "4",
doi = "10.1073/pnas.2021660118",
language = "English (US)",
volume = "118",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "18",
}