Plant glutamate receptors mediate a bet-hedging strategy between regeneration and defense

Marcela Hernández-Coronado, Poliana Coqueiro Dias Araujo, Pui Leng Ip, Custódio O. Nunes, Ramin Rahni, Michael M. Wudick, Michael A. Lizzio, José A. Feijó, Kenneth D. Birnbaum

Research output: Contribution to journalArticlepeer-review

Abstract

Wounding is a trigger for both regeneration and defense in plants, but it is not clear whether the two responses are linked by common activation or regulated as trade-offs. Although plant glutamate-receptor-like proteins (GLRs) are known to mediate defense responses, here, we implicate GLRs in regeneration through dynamic changes in chromatin and transcription in reprogramming cells near wound sites. We show that genetic and pharmacological inhibition of GLR activity increases regeneration efficiency in multiple organ repair systems in Arabidopsis and maize. We show that the GLRs work through salicylic acid (SA) signaling in their effects on regeneration, and mutants in the SA receptor NPR1 are hyper-regenerative and partially resistant to GLR perturbation. These findings reveal a conserved mechanism that regulates a trade-off between defense and regeneration, and they also offer a strategy to improve regeneration in agriculture and conservation.

Original languageEnglish (US)
Pages (from-to)451-465.e6
JournalDevelopmental Cell
Volume57
Issue number4
DOIs
StatePublished - Feb 28 2022

Keywords

  • callus formation
  • developmental genetics
  • ion channel signaling
  • plant biotechnology
  • plant defense
  • plant regeneration
  • root development
  • salicyclic acid signaling
  • stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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