Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection

S. I. Shopova; R. Rajmangal; S. Holler; S. Arnold

doi:10.1063/1.3599584

Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection

S. I. Shopova, R. Rajmangal, S. Holler, S. Arnold

Research output: Contribution to journal › Article › peer-review

Abstract

We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a whispering-gallery-mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound at the microparticle's equator. As the dielectric particle parks to hot spots on the plasmonic particle we observe frequency shifts that are enhanced by a factor of 4, consistent with a simple reactive model. Once optimized the enhancement by this mechanism should exceed several orders of magnitude, putting individual protein within reach.

Original language	English (US)
Article number	243104
Journal	Applied Physics Letters
Volume	98
Issue number	24
DOIs	https://doi.org/10.1063/1.3599584
State	Published - Jun 13 2011

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.3599584

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title = "Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection",

abstract = "We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a whispering-gallery-mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound at the microparticle's equator. As the dielectric particle parks to hot spots on the plasmonic particle we observe frequency shifts that are enhanced by a factor of 4, consistent with a simple reactive model. Once optimized the enhancement by this mechanism should exceed several orders of magnitude, putting individual protein within reach.",

author = "Shopova, {S. I.} and R. Rajmangal and S. Holler and S. Arnold",

note = "Funding Information: The authors thank the NSF for supporting this work (Grant No. CBET 0933531). We are also grateful to William Chin of the for preparing Fig. .",

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AU - Rajmangal, R.

AU - Holler, S.

AU - Arnold, S.

N1 - Funding Information: The authors thank the NSF for supporting this work (Grant No. CBET 0933531). We are also grateful to William Chin of the for preparing Fig. .

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Y1 - 2011/6/13

N2 - We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a whispering-gallery-mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound at the microparticle's equator. As the dielectric particle parks to hot spots on the plasmonic particle we observe frequency shifts that are enhanced by a factor of 4, consistent with a simple reactive model. Once optimized the enhancement by this mechanism should exceed several orders of magnitude, putting individual protein within reach.

AB - We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a whispering-gallery-mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound at the microparticle's equator. As the dielectric particle parks to hot spots on the plasmonic particle we observe frequency shifts that are enhanced by a factor of 4, consistent with a simple reactive model. Once optimized the enhancement by this mechanism should exceed several orders of magnitude, putting individual protein within reach.

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Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection

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