Abstract
Development of specific ligands for protein targets that help decode the complexities of protein-protein interaction networks is a key goal for the field of chemical biology. Despite the emergence of powerful in silico and experimental high-throughput screening strategies, the discovery of synthetic ligands that selectively modulate protein-protein interactions remains a challenge for bioorganic and medicinal chemists. This Perspective discusses emerging principles for the rational design of PPI inhibitors. Fundamentally, the approach seeks to adapt nature's protein recognition principles for the design of suitable secondary structure mimetics.
Original language | English (US) |
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Pages (from-to) | 4051-4057 |
Number of pages | 7 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 21 |
Issue number | 14 |
DOIs | |
State | Published - Jul 15 2013 |
Keywords
- Computational design
- Hot spot residues
- Protein-protein interactions
- Rational design
- Secondary structure mimics
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry