Polarimetric imaging of amyloid

Werner Kaminksy; Lee Way Jin; Steven Powell; Izumi Maezawa; Kacey Claborn; Charles Branham; Bart Kahr

doi:10.1016/j.micron.2005.10.014

Polarimetric imaging of amyloid

Werner Kaminksy, Lee Way Jin, Steven Powell, Izumi Maezawa, Kacey Claborn, Charles Branham, Bart Kahr

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that are pathognomonic of a variety of degenerative disorders. We present the results of linear birefringence, linear dichroism, and circular dichroism imaging of Congo red stained plaques ex vivo and in vitro. A new technique for measuring rapid changes in linear anisotropies is introduced. The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures.

Original language	English (US)
Pages (from-to)	324-338
Number of pages	15
Journal	Micron
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/j.micron.2005.10.014
State	Published - Jun 2006

Keywords

Alzheimer's disease
Amyloidosis
Circular dichroism
Circular extinction
Congo red
Linear birefringence
Linear dichroism

ASJC Scopus subject areas

Structural Biology
Materials Science(all)
Physics and Astronomy(all)
Cell Biology

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10.1016/j.micron.2005.10.014

Cite this

@article{a246da36fc1b4299ac533a37cf9d402e,

title = "Polarimetric imaging of amyloid",

abstract = "New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that are pathognomonic of a variety of degenerative disorders. We present the results of linear birefringence, linear dichroism, and circular dichroism imaging of Congo red stained plaques ex vivo and in vitro. A new technique for measuring rapid changes in linear anisotropies is introduced. The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures.",

keywords = "Alzheimer's disease, Amyloidosis, Circular dichroism, Circular extinction, Congo red, Linear birefringence, Linear dichroism",

author = "Werner Kaminksy and Jin, {Lee Way} and Steven Powell and Izumi Maezawa and Kacey Claborn and Charles Branham and Bart Kahr",

note = "Funding Information: This work was supported by the National Science Foundation (CHE-0092617), the National Institutes of Health/National Institute on Aging (5P30 AG10129), and the Royalty Research Fund of the University of Washington. KC thanks the Organic Chemistry Division of the American Chemical Society for a fellowship sponsored by Organic Reactions Inc.",

year = "2006",

month = jun,

doi = "10.1016/j.micron.2005.10.014",

language = "English (US)",

volume = "37",

pages = "324--338",

journal = "Micron",

issn = "0968-4328",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Polarimetric imaging of amyloid

AU - Kaminksy, Werner

AU - Jin, Lee Way

AU - Powell, Steven

AU - Maezawa, Izumi

AU - Claborn, Kacey

AU - Branham, Charles

AU - Kahr, Bart

N1 - Funding Information: This work was supported by the National Science Foundation (CHE-0092617), the National Institutes of Health/National Institute on Aging (5P30 AG10129), and the Royalty Research Fund of the University of Washington. KC thanks the Organic Chemistry Division of the American Chemical Society for a fellowship sponsored by Organic Reactions Inc.

PY - 2006/6

Y1 - 2006/6

N2 - New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that are pathognomonic of a variety of degenerative disorders. We present the results of linear birefringence, linear dichroism, and circular dichroism imaging of Congo red stained plaques ex vivo and in vitro. A new technique for measuring rapid changes in linear anisotropies is introduced. The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures.

AB - New developments in optical microscopy are discussed with relevance to the imaging of amyloid plaques that are pathognomonic of a variety of degenerative disorders. We present the results of linear birefringence, linear dichroism, and circular dichroism imaging of Congo red stained plaques ex vivo and in vitro. A new technique for measuring rapid changes in linear anisotropies is introduced. The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures.

KW - Alzheimer's disease

KW - Amyloidosis

KW - Circular dichroism

KW - Circular extinction

KW - Congo red

KW - Linear birefringence

KW - Linear dichroism

UR - http://www.scopus.com/inward/record.url?scp=33646589981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646589981&partnerID=8YFLogxK

U2 - 10.1016/j.micron.2005.10.014

DO - 10.1016/j.micron.2005.10.014

M3 - Review article

C2 - 16406217

AN - SCOPUS:33646589981

SN - 0968-4328

VL - 37

SP - 324

EP - 338

JO - Micron

JF - Micron

IS - 4

ER -

Polarimetric imaging of amyloid

Abstract

Keywords

ASJC Scopus subject areas

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