Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh

M. Hafizur Rahman; M. Iqbal Arslan; Yu Chen; Suhrab Ali; Tanzeema Parvin; Lian Wen Wang; Regina M. Santella; Habibul Ahsan

doi:10.1007/s00420-003-0431-z

Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh

M. Hafizur Rahman, M. Iqbal Arslan, Yu Chen, Suhrab Ali, Tanzeema Parvin, Lian Wen Wang, Regina M. Santella, Habibul Ahsan

Urban Initiative

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes findings from a recently completed study of polycyclic aromatic hydrocarbon (PAH) exposure among city dwellers of Dhaka, Bangladesh. We measured PAH-DNA adducts in white blood cells (WBCs) as a marker of environmental and occupational PAH exposure in 46 rickshaw drivers (who pedal commercial unshielded three-wheelers for passenger transport) and 48 non-rickshaw drivers (comparison group) in Dhaka city. We performed enzyme-linked immunosorbent assay (ELISA) to quantify immunologically the WBC PAH-DNA adducts. Rickshaw drivers had a significantly higher WBC PAH-DNA adducts level than the non-rickshaw drivers. Among rickshaw drivers, adduct levels tended to be positively associated with the duration of residence in the city and cigarette smoking. No such trends were observed among non-rickshaw drivers. In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds.

Original language	English (US)
Pages (from-to)	533-538
Number of pages	6
Journal	International Archives of Occupational and Environmental Health
Volume	76
Issue number	7
DOIs	https://doi.org/10.1007/s00420-003-0431-z
State	Published - Sep 2003

Keywords

Bangladesh
Environmental pollution
Molecular epidemiology
PAH-DNA adducts
Polycyclic aromatic hydrocarbon (PAH)
Rickshaw drivers

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1007/s00420-003-0431-z

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title = "Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh",

abstract = "This paper describes findings from a recently completed study of polycyclic aromatic hydrocarbon (PAH) exposure among city dwellers of Dhaka, Bangladesh. We measured PAH-DNA adducts in white blood cells (WBCs) as a marker of environmental and occupational PAH exposure in 46 rickshaw drivers (who pedal commercial unshielded three-wheelers for passenger transport) and 48 non-rickshaw drivers (comparison group) in Dhaka city. We performed enzyme-linked immunosorbent assay (ELISA) to quantify immunologically the WBC PAH-DNA adducts. Rickshaw drivers had a significantly higher WBC PAH-DNA adducts level than the non-rickshaw drivers. Among rickshaw drivers, adduct levels tended to be positively associated with the duration of residence in the city and cigarette smoking. No such trends were observed among non-rickshaw drivers. In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds.",

keywords = "Bangladesh, Environmental pollution, Molecular epidemiology, PAH-DNA adducts, Polycyclic aromatic hydrocarbon (PAH), Rickshaw drivers",

author = "Rahman, {M. Hafizur} and Arslan, {M. Iqbal} and Yu Chen and Suhrab Ali and Tanzeema Parvin and Wang, {Lian Wen} and Santella, {Regina M.} and Habibul Ahsan",

note = "Funding Information: Acknowledgement This work was supported by National Institute of Environmental Health Sciences Grant (P30 ES09089).",

year = "2003",

month = sep,

doi = "10.1007/s00420-003-0431-z",

language = "English (US)",

volume = "76",

pages = "533--538",

journal = "International Archives of Occupational and Environmental Health",

issn = "0340-0131",

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T1 - Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh

AU - Rahman, M. Hafizur

AU - Arslan, M. Iqbal

AU - Chen, Yu

AU - Ali, Suhrab

AU - Parvin, Tanzeema

AU - Wang, Lian Wen

AU - Santella, Regina M.

AU - Ahsan, Habibul

N1 - Funding Information: Acknowledgement This work was supported by National Institute of Environmental Health Sciences Grant (P30 ES09089).

PY - 2003/9

Y1 - 2003/9

N2 - This paper describes findings from a recently completed study of polycyclic aromatic hydrocarbon (PAH) exposure among city dwellers of Dhaka, Bangladesh. We measured PAH-DNA adducts in white blood cells (WBCs) as a marker of environmental and occupational PAH exposure in 46 rickshaw drivers (who pedal commercial unshielded three-wheelers for passenger transport) and 48 non-rickshaw drivers (comparison group) in Dhaka city. We performed enzyme-linked immunosorbent assay (ELISA) to quantify immunologically the WBC PAH-DNA adducts. Rickshaw drivers had a significantly higher WBC PAH-DNA adducts level than the non-rickshaw drivers. Among rickshaw drivers, adduct levels tended to be positively associated with the duration of residence in the city and cigarette smoking. No such trends were observed among non-rickshaw drivers. In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds.

AB - This paper describes findings from a recently completed study of polycyclic aromatic hydrocarbon (PAH) exposure among city dwellers of Dhaka, Bangladesh. We measured PAH-DNA adducts in white blood cells (WBCs) as a marker of environmental and occupational PAH exposure in 46 rickshaw drivers (who pedal commercial unshielded three-wheelers for passenger transport) and 48 non-rickshaw drivers (comparison group) in Dhaka city. We performed enzyme-linked immunosorbent assay (ELISA) to quantify immunologically the WBC PAH-DNA adducts. Rickshaw drivers had a significantly higher WBC PAH-DNA adducts level than the non-rickshaw drivers. Among rickshaw drivers, adduct levels tended to be positively associated with the duration of residence in the city and cigarette smoking. No such trends were observed among non-rickshaw drivers. In conclusion, the results suggest that urban residents who are occupationally exposed to traffic pollution in Dhaka are at potentially higher risk of health effects from exposure to carcinogenic PAH compounds.

KW - Bangladesh

KW - Environmental pollution

KW - Molecular epidemiology

KW - PAH-DNA adducts

KW - Polycyclic aromatic hydrocarbon (PAH)

KW - Rickshaw drivers

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Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh

Abstract

Keywords

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