Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A. Rietveld, Abdel Abdellaoui, Michel M. Nivard, Magnus Johannesson, Tessel E. Galesloot, Jouke J. Hottenga, Gonneke Willemsen, David Cesarini, Daniel J. Benjamin, Patrik K.E. Magnusson, Fredrik Ullén, Henning Tiemeier, Albert Hofman, Frank J.A. Van Rooij, G. Bragi Walters, Engilbert Sigurdsson, Thorgeir E. ThorgeirssonAndres Ingason, Agnar Helgason, Augustine Kong, Lambertus A. Kiemeney, Philipp Koellinger, Dorret I. Boomsma, Daniel Gudbjartsson, Hreinn Stefansson, Kari Stefansson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

    Original languageEnglish (US)
    Pages (from-to)953-955
    Number of pages3
    JournalNature Neuroscience
    Volume18
    Issue number7
    DOIs
    StatePublished - Jun 25 2015

    ASJC Scopus subject areas

    • Neuroscience(all)

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