TY - JOUR
T1 - Polygenic risk scores for schizophrenia and bipolar disorder predict creativity
AU - Power, Robert A.
AU - Steinberg, Stacy
AU - Bjornsdottir, Gyda
AU - Rietveld, Cornelius A.
AU - Abdellaoui, Abdel
AU - Nivard, Michel M.
AU - Johannesson, Magnus
AU - Galesloot, Tessel E.
AU - Hottenga, Jouke J.
AU - Willemsen, Gonneke
AU - Cesarini, David
AU - Benjamin, Daniel J.
AU - Magnusson, Patrik K.E.
AU - Ullén, Fredrik
AU - Tiemeier, Henning
AU - Hofman, Albert
AU - Van Rooij, Frank J.A.
AU - Walters, G. Bragi
AU - Sigurdsson, Engilbert
AU - Thorgeirsson, Thorgeir E.
AU - Ingason, Andres
AU - Helgason, Agnar
AU - Kong, Augustine
AU - Kiemeney, Lambertus A.
AU - Koellinger, Philipp
AU - Boomsma, Dorret I.
AU - Gudbjartsson, Daniel
AU - Stefansson, Hreinn
AU - Stefansson, Kari
N1 - Publisher Copyright:
© 2015 Nature America, Inc.
PY - 2015/6/25
Y1 - 2015/6/25
N2 - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
AB - We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.
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U2 - 10.1038/nn.4040
DO - 10.1038/nn.4040
M3 - Article
C2 - 26053403
AN - SCOPUS:84933054270
SN - 1097-6256
VL - 18
SP - 953
EP - 955
JO - Nature Neuroscience
JF - Nature Neuroscience
IS - 7
ER -