Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power; Stacy Steinberg; Gyda Bjornsdottir; Cornelius A. Rietveld; Abdel Abdellaoui; Michel M. Nivard; Magnus Johannesson; Tessel E. Galesloot; Jouke J. Hottenga; Gonneke Willemsen; David Cesarini; Daniel J. Benjamin; Patrik K.E. Magnusson; Fredrik Ullén; Henning Tiemeier; Albert Hofman; Frank J.A. Van Rooij; G. Bragi Walters; Engilbert Sigurdsson; Thorgeir E. Thorgeirsson; Andres Ingason; Agnar Helgason; Augustine Kong; Lambertus A. Kiemeney; Philipp Koellinger; Dorret I. Boomsma; Daniel Gudbjartsson; Hreinn Stefansson; Kari Stefansson

doi:10.1038/nn.4040

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A. Rietveld, Abdel Abdellaoui, Michel M. Nivard, Magnus Johannesson, Tessel E. Galesloot, Jouke J. Hottenga, Gonneke Willemsen, David Cesarini, Daniel J. Benjamin, Patrik K.E. Magnusson, Fredrik Ullén, Henning Tiemeier, Albert Hofman, Frank J.A. Van Rooij, G. Bragi Walters, Engilbert Sigurdsson, Thorgeir E. ThorgeirssonAndres Ingason, Agnar Helgason, Augustine Kong, Lambertus A. Kiemeney, Philipp Koellinger, Dorret I. Boomsma, Daniel Gudbjartsson, Hreinn Stefansson, Kari Stefansson

Research output: Contribution to journal › Article › peer-review

Abstract

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

Original language	English (US)
Pages (from-to)	953-955
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nn.4040
State	Published - Jun 25 2015

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn.4040

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Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. M., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K. E., Ullén, F., Tiemeier, H., Hofman, A., Van Rooij, F. J. A., Walters, G. B., Sigurdsson, E., ... Stefansson, K. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience, 18(7), 953-955. https://doi.org/10.1038/nn.4040

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. / Power, Robert A.; Steinberg, Stacy; Bjornsdottir, Gyda; Rietveld, Cornelius A.; Abdellaoui, Abdel; Nivard, Michel M.; Johannesson, Magnus; Galesloot, Tessel E.; Hottenga, Jouke J.; Willemsen, Gonneke; Cesarini, David; Benjamin, Daniel J.; Magnusson, Patrik K.E.; Ullén, Fredrik; Tiemeier, Henning; Hofman, Albert; Van Rooij, Frank J.A.; Walters, G. Bragi; Sigurdsson, Engilbert; Thorgeirsson, Thorgeir E.; Ingason, Andres; Helgason, Agnar; Kong, Augustine; Kiemeney, Lambertus A.; Koellinger, Philipp; Boomsma, Dorret I.; Gudbjartsson, Daniel; Stefansson, Hreinn; Stefansson, Kari.

In: Nature Neuroscience, Vol. 18, No. 7, 25.06.2015, p. 953-955.

Research output: Contribution to journal › Article › peer-review

Power, RA, Steinberg, S, Bjornsdottir, G, Rietveld, CA, Abdellaoui, A, Nivard, MM, Johannesson, M, Galesloot, TE, Hottenga, JJ, Willemsen, G, Cesarini, D, Benjamin, DJ, Magnusson, PKE, Ullén, F, Tiemeier, H, Hofman, A, Van Rooij, FJA, Walters, GB, Sigurdsson, E, Thorgeirsson, TE, Ingason, A, Helgason, A, Kong, A, Kiemeney, LA, Koellinger, P, Boomsma, DI, Gudbjartsson, D, Stefansson, H & Stefansson, K 2015, 'Polygenic risk scores for schizophrenia and bipolar disorder predict creativity', Nature Neuroscience, vol. 18, no. 7, pp. 953-955. https://doi.org/10.1038/nn.4040

Power, Robert A. ; Steinberg, Stacy ; Bjornsdottir, Gyda ; Rietveld, Cornelius A. ; Abdellaoui, Abdel ; Nivard, Michel M. ; Johannesson, Magnus ; Galesloot, Tessel E. ; Hottenga, Jouke J. ; Willemsen, Gonneke ; Cesarini, David ; Benjamin, Daniel J. ; Magnusson, Patrik K.E. ; Ullén, Fredrik ; Tiemeier, Henning ; Hofman, Albert ; Van Rooij, Frank J.A. ; Walters, G. Bragi ; Sigurdsson, Engilbert ; Thorgeirsson, Thorgeir E. ; Ingason, Andres ; Helgason, Agnar ; Kong, Augustine ; Kiemeney, Lambertus A. ; Koellinger, Philipp ; Boomsma, Dorret I. ; Gudbjartsson, Daniel ; Stefansson, Hreinn ; Stefansson, Kari. / Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. In: Nature Neuroscience. 2015 ; Vol. 18, No. 7. pp. 953-955.

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AU - Nivard, Michel M.

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