Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power; Stacy Steinberg; Gyda Bjornsdottir; Cornelius A. Rietveld; Abdel Abdellaoui; Michel M. Nivard; Magnus Johannesson; Tessel E. Galesloot; Jouke J. Hottenga; Gonneke Willemsen; David Cesarini; Daniel J. Benjamin; Patrik K.E. Magnusson; Fredrik Ullén; Henning Tiemeier; Albert Hofman; Frank J.A. Van Rooij; G. Bragi Walters; Engilbert Sigurdsson; Thorgeir E. Thorgeirsson; Andres Ingason; Agnar Helgason; Augustine Kong; Lambertus A. Kiemeney; Philipp Koellinger; Dorret I. Boomsma; Daniel Gudbjartsson; Hreinn Stefansson; Kari Stefansson

doi:10.1038/nn.4040

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Robert A. Power, Stacy Steinberg, Gyda Bjornsdottir, Cornelius A. Rietveld, Abdel Abdellaoui, Michel M. Nivard, Magnus Johannesson, Tessel E. Galesloot, Jouke J. Hottenga, Gonneke Willemsen, David Cesarini, Daniel J. Benjamin, Patrik K.E. Magnusson, Fredrik Ullén, Henning Tiemeier, Albert Hofman, Frank J.A. Van Rooij, G. Bragi Walters, Engilbert Sigurdsson, Thorgeir E. ThorgeirssonAndres Ingason, Agnar Helgason, Augustine Kong, Lambertus A. Kiemeney, Philipp Koellinger, Dorret I. Boomsma, Daniel Gudbjartsson, Hreinn Stefansson, Kari Stefansson

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Abstract

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 â '6 and 3.8 × 10 â '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.

Original language	English (US)
Pages (from-to)	953-955
Number of pages	3
Journal	Nature Neuroscience
Volume	18
Issue number	7
DOIs	https://doi.org/10.1038/nn.4040
State	Published - Jun 25 2015

ASJC Scopus subject areas

General Neuroscience

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Power, R. A., Steinberg, S., Bjornsdottir, G., Rietveld, C. A., Abdellaoui, A., Nivard, M. M., Johannesson, M., Galesloot, T. E., Hottenga, J. J., Willemsen, G., Cesarini, D., Benjamin, D. J., Magnusson, P. K. E., Ullén, F., Tiemeier, H., Hofman, A., Van Rooij, F. J. A., Walters, G. B., Sigurdsson, E., ... Stefansson, K. (2015). Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nature Neuroscience, 18(7), 953-955. https://doi.org/10.1038/nn.4040

Power, RA, Steinberg, S, Bjornsdottir, G, Rietveld, CA, Abdellaoui, A, Nivard, MM, Johannesson, M, Galesloot, TE, Hottenga, JJ, Willemsen, G, Cesarini, D, Benjamin, DJ, Magnusson, PKE, Ullén, F, Tiemeier, H, Hofman, A, Van Rooij, FJA, Walters, GB, Sigurdsson, E, Thorgeirsson, TE, Ingason, A, Helgason, A, Kong, A, Kiemeney, LA, Koellinger, P, Boomsma, DI, Gudbjartsson, D, Stefansson, H & Stefansson, K 2015, 'Polygenic risk scores for schizophrenia and bipolar disorder predict creativity', Nature Neuroscience, vol. 18, no. 7, pp. 953-955. https://doi.org/10.1038/nn.4040

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abstract = "We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10 {\^a} '6 and 3.8 × 10 {\^a} '6 for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness between creative individuals and those with psychoses, indicating that creativity and psychosis share genetic roots.",

author = "Power, {Robert A.} and Stacy Steinberg and Gyda Bjornsdottir and Rietveld, {Cornelius A.} and Abdel Abdellaoui and Nivard, {Michel M.} and Magnus Johannesson and Galesloot, {Tessel E.} and Hottenga, {Jouke J.} and Gonneke Willemsen and David Cesarini and Benjamin, {Daniel J.} and Magnusson, {Patrik K.E.} and Fredrik Ull{\'e}n and Henning Tiemeier and Albert Hofman and {Van Rooij}, {Frank J.A.} and Walters, {G. Bragi} and Engilbert Sigurdsson and Thorgeirsson, {Thorgeir E.} and Andres Ingason and Agnar Helgason and Augustine Kong and Kiemeney, {Lambertus A.} and Philipp Koellinger and Boomsma, {Dorret I.} and Daniel Gudbjartsson and Hreinn Stefansson and Kari Stefansson",

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AU - Bjornsdottir, Gyda

AU - Rietveld, Cornelius A.

AU - Abdellaoui, Abdel

AU - Nivard, Michel M.

AU - Johannesson, Magnus

AU - Galesloot, Tessel E.

AU - Hottenga, Jouke J.

AU - Willemsen, Gonneke

AU - Cesarini, David

AU - Benjamin, Daniel J.

AU - Magnusson, Patrik K.E.

AU - Ullén, Fredrik

AU - Tiemeier, Henning

AU - Hofman, Albert

AU - Van Rooij, Frank J.A.

AU - Walters, G. Bragi

AU - Sigurdsson, Engilbert

AU - Thorgeirsson, Thorgeir E.

AU - Ingason, Andres

AU - Helgason, Agnar

AU - Kong, Augustine

AU - Kiemeney, Lambertus A.

AU - Koellinger, Philipp

AU - Boomsma, Dorret I.

AU - Gudbjartsson, Daniel

AU - Stefansson, Hreinn

AU - Stefansson, Kari

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Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

Abstract

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