Polymeric biomaterials with degradation sites for proteases involved in cell migration

Jennifer L. West; Jeffrey A. Hubbell

doi:10.1021/ma981296k

Polymeric biomaterials with degradation sites for proteases involved in cell migration

Jennifer L. West, Jeffrey A. Hubbell

Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A new class of biodegradable polymeric biomaterials is described which exhibits degradation by specific enzymes that are localized near cell surfaces during cell migration. These materials are telechelic BAB block copolymers of the water-soluble biocompatible polymer, polyethylene glycol (A block) and short oligopeptide that are cleavage sequences for targeted enzymes (B block). These polymers are further capped at each end with reactive acrylate groups to allow polymerization to form crosslinked hydrogel networks. The combination of two types of bioactive signals, one for cell-mediated degradation, and one for cell adhesion, into one material should achieve a biomemitic polymeric hydrogel with properties of natural extracellular matrix.

Original language	English (US)
Pages (from-to)	241-244
Number of pages	4
Journal	Macromolecules
Volume	32
Issue number	1
DOIs	https://doi.org/10.1021/ma981296k
State	Published - Jan 1 1999

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1021/ma981296k

Cite this

@article{5cd05161c57144b589de9a4fbe79a39e,

title = "Polymeric biomaterials with degradation sites for proteases involved in cell migration",

abstract = "A new class of biodegradable polymeric biomaterials is described which exhibits degradation by specific enzymes that are localized near cell surfaces during cell migration. These materials are telechelic BAB block copolymers of the water-soluble biocompatible polymer, polyethylene glycol (A block) and short oligopeptide that are cleavage sequences for targeted enzymes (B block). These polymers are further capped at each end with reactive acrylate groups to allow polymerization to form crosslinked hydrogel networks. The combination of two types of bioactive signals, one for cell-mediated degradation, and one for cell adhesion, into one material should achieve a biomemitic polymeric hydrogel with properties of natural extracellular matrix.",

author = "West, {Jennifer L.} and Hubbell, {Jeffrey A.}",

year = "1999",

month = jan,

day = "1",

doi = "10.1021/ma981296k",

language = "English (US)",

volume = "32",

pages = "241--244",

journal = "Macromolecules",

issn = "0024-9297",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Polymeric biomaterials with degradation sites for proteases involved in cell migration

AU - West, Jennifer L.

AU - Hubbell, Jeffrey A.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - A new class of biodegradable polymeric biomaterials is described which exhibits degradation by specific enzymes that are localized near cell surfaces during cell migration. These materials are telechelic BAB block copolymers of the water-soluble biocompatible polymer, polyethylene glycol (A block) and short oligopeptide that are cleavage sequences for targeted enzymes (B block). These polymers are further capped at each end with reactive acrylate groups to allow polymerization to form crosslinked hydrogel networks. The combination of two types of bioactive signals, one for cell-mediated degradation, and one for cell adhesion, into one material should achieve a biomemitic polymeric hydrogel with properties of natural extracellular matrix.

AB - A new class of biodegradable polymeric biomaterials is described which exhibits degradation by specific enzymes that are localized near cell surfaces during cell migration. These materials are telechelic BAB block copolymers of the water-soluble biocompatible polymer, polyethylene glycol (A block) and short oligopeptide that are cleavage sequences for targeted enzymes (B block). These polymers are further capped at each end with reactive acrylate groups to allow polymerization to form crosslinked hydrogel networks. The combination of two types of bioactive signals, one for cell-mediated degradation, and one for cell adhesion, into one material should achieve a biomemitic polymeric hydrogel with properties of natural extracellular matrix.

UR - http://www.scopus.com/inward/record.url?scp=0032737267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032737267&partnerID=8YFLogxK

U2 - 10.1021/ma981296k

DO - 10.1021/ma981296k

M3 - Article

AN - SCOPUS:0032737267

SN - 0024-9297

VL - 32

SP - 241

EP - 244

JO - Macromolecules

JF - Macromolecules

IS - 1

ER -

Polymeric biomaterials with degradation sites for proteases involved in cell migration

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this