TY - JOUR
T1 - Polymorphisms in Tumor Necrosis Factor-α Are Associated with Higher Anxiety Levels in Women after Breast Cancer Surgery
AU - Miaskowski, Christine
AU - Elboim, Charles
AU - Paul, Steven M.
AU - Mastick, Judy
AU - Cooper, Bruce A.
AU - Levine, Jon D.
AU - Aouizerat, Bradley E.
N1 - Funding Information:
The present study was funded by grants from the National Cancer Institute (NCI; CA107091 and CA118658 ). Dr. Christine Miaskowski is an American Cancer Society Clinical Research Professor and is supported by a K05 award from the NCI (CA168960). This project is supported by National Institutes of Health (NIH)/ National Center for Research Resources University of California, San Francisco, Clinical and Translational Science Institute (grant UL1 RR024131 ). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Introduction Before and after breast cancer surgery, women have reported varying anxiety levels. Recent evidence has suggested that anxiety has a genetic basis and is associated with inflammation. The purposes of the present study were to identify the subgroups of women with distinct anxiety trajectories; to evaluate for differences in the phenotypic characteristics between these subgroups; and to evaluate for associations between polymorphisms in cytokine genes and subgroup membership. Patients and Methods Patients with breast cancer (n = 398) were recruited before surgery and followed up for 6 months. The patients completed the Spielberger State Anxiety Inventory and provided a blood sample for genomic analyses. Growth mixture modeling was used to identify the subgroups of patients with distinct anxiety trajectories. Results Two distinct anxiety subgroups were identified. The women in the higher anxiety subgroup were younger and had a lower functional status score. Two single nucleotide polymorphisms in tumor necrosis factor-α (rs1799964, rs3093662) were associated with the higher anxiety subgroup. Conclusion The results of the present exploratory study suggest that polymorphisms in cytokine genes could partially explain the interindividual variability in anxiety. The determination of phenotypic and molecular markers associated with greater levels of anxiety can assist clinicians to identify high-risk patients and initiate appropriate interventions.
AB - Introduction Before and after breast cancer surgery, women have reported varying anxiety levels. Recent evidence has suggested that anxiety has a genetic basis and is associated with inflammation. The purposes of the present study were to identify the subgroups of women with distinct anxiety trajectories; to evaluate for differences in the phenotypic characteristics between these subgroups; and to evaluate for associations between polymorphisms in cytokine genes and subgroup membership. Patients and Methods Patients with breast cancer (n = 398) were recruited before surgery and followed up for 6 months. The patients completed the Spielberger State Anxiety Inventory and provided a blood sample for genomic analyses. Growth mixture modeling was used to identify the subgroups of patients with distinct anxiety trajectories. Results Two distinct anxiety subgroups were identified. The women in the higher anxiety subgroup were younger and had a lower functional status score. Two single nucleotide polymorphisms in tumor necrosis factor-α (rs1799964, rs3093662) were associated with the higher anxiety subgroup. Conclusion The results of the present exploratory study suggest that polymorphisms in cytokine genes could partially explain the interindividual variability in anxiety. The determination of phenotypic and molecular markers associated with greater levels of anxiety can assist clinicians to identify high-risk patients and initiate appropriate interventions.
KW - Cytokine genes
KW - Depression
KW - Growth mixture modeling
KW - Psychological distress
KW - Symptom trajectories
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U2 - 10.1016/j.clbc.2014.12.001
DO - 10.1016/j.clbc.2014.12.001
M3 - Article
C2 - 25813148
AN - SCOPUS:84952874028
SN - 1526-8209
VL - 16
SP - 63-71.e3
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
IS - 1
ER -