Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

Daniel N. Hupalo; Zunping Luo; Alexandre Melnikov; Patrick L. Sutton; Peter Rogov; Ananias Escalante; Andrés F. Vallejo; Sócrates Herrera; Myriam Arévalo-Herrera; Qi Fan; Ying Wang; Liwang Cui; Carmen M. Lucas; Salomon Durand; Juan F. Sanchez; G. Christian Baldeviano; Andres G. Lescano; Moses Laman; Celine Barnadas; Alyssa Barry; Ivo Mueller; James W. Kazura; Alex Eapen; Deena Kanagaraj; Neena Valecha; Marcelo U. Ferreira; Wanlapa Roobsoong; Wang Nguitragool; Jetsumon Sattabonkot; Dionicia Gamboa; Margaret Kosek; Joseph M. Vinetz; Lilia González-Cerón; Bruce W. Birren; Daniel E. Neafsey; Jane M. Carlton

doi:10.1038/ng.3588

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

Daniel N. Hupalo, Zunping Luo, Alexandre Melnikov, Patrick L. Sutton, Peter Rogov, Ananias Escalante, Andrés F. Vallejo, Sócrates Herrera, Myriam Arévalo-Herrera, Qi Fan, Ying Wang, Liwang Cui, Carmen M. Lucas, Salomon Durand, Juan F. Sanchez, G. Christian Baldeviano, Andres G. Lescano, Moses Laman, Celine Barnadas, Alyssa BarryIvo Mueller, James W. Kazura, Alex Eapen, Deena Kanagaraj, Neena Valecha, Marcelo U. Ferreira, Wanlapa Roobsoong, Wang Nguitragool, Jetsumon Sattabonkot, Dionicia Gamboa, Margaret Kosek, Joseph M. Vinetz, Lilia González-Cerón, Bruce W. Birren, Daniel E. Neafsey, Jane M. Carlton

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Abstract

Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally.

Original language	English (US)
Pages (from-to)	953-958
Number of pages	6
Journal	Nature Genetics
Volume	48
Issue number	8
DOIs	https://doi.org/10.1038/ng.3588
State	Published - Aug 1 2016

ASJC Scopus subject areas

Genetics

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Hupalo, D. N., Luo, Z., Melnikov, A., Sutton, P. L., Rogov, P., Escalante, A., Vallejo, A. F., Herrera, S., Arévalo-Herrera, M., Fan, Q., Wang, Y., Cui, L., Lucas, C. M., Durand, S., Sanchez, J. F., Christian Baldeviano, G., Lescano, A. G., Laman, M., Barnadas, C., ... Carlton, J. M. (2016). Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax. Nature Genetics, 48(8), 953-958. https://doi.org/10.1038/ng.3588

Hupalo, DN, Luo, Z, Melnikov, A, Sutton, PL, Rogov, P, Escalante, A, Vallejo, AF, Herrera, S, Arévalo-Herrera, M, Fan, Q, Wang, Y, Cui, L, Lucas, CM, Durand, S, Sanchez, JF, Christian Baldeviano, G, Lescano, AG, Laman, M, Barnadas, C, Barry, A, Mueller, I, Kazura, JW, Eapen, A, Kanagaraj, D, Valecha, N, Ferreira, MU, Roobsoong, W, Nguitragool, W, Sattabonkot, J, Gamboa, D, Kosek, M, Vinetz, JM, González-Cerón, L, Birren, BW, Neafsey, DE & Carlton, JM 2016, 'Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax', Nature Genetics, vol. 48, no. 8, pp. 953-958. https://doi.org/10.1038/ng.3588

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title = "Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax",

abstract = "Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally.",

author = "Hupalo, {Daniel N.} and Zunping Luo and Alexandre Melnikov and Sutton, {Patrick L.} and Peter Rogov and Ananias Escalante and Vallejo, {Andr{\'e}s F.} and S{\'o}crates Herrera and Myriam Ar{\'e}valo-Herrera and Qi Fan and Ying Wang and Liwang Cui and Lucas, {Carmen M.} and Salomon Durand and Sanchez, {Juan F.} and {Christian Baldeviano}, G. and Lescano, {Andres G.} and Moses Laman and Celine Barnadas and Alyssa Barry and Ivo Mueller and Kazura, {James W.} and Alex Eapen and Deena Kanagaraj and Neena Valecha and Ferreira, {Marcelo U.} and Wanlapa Roobsoong and Wang Nguitragool and Jetsumon Sattabonkot and Dionicia Gamboa and Margaret Kosek and Vinetz, {Joseph M.} and Lilia Gonz{\'a}lez-Cer{\'o}n and Birren, {Bruce W.} and Neafsey, {Daniel E.} and Carlton, {Jane M.}",

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doi = "10.1038/ng.3588",

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AU - Hupalo, Daniel N.

AU - Luo, Zunping

AU - Melnikov, Alexandre

AU - Sutton, Patrick L.

AU - Rogov, Peter

AU - Escalante, Ananias

AU - Vallejo, Andrés F.

AU - Herrera, Sócrates

AU - Arévalo-Herrera, Myriam

AU - Fan, Qi

AU - Wang, Ying

AU - Cui, Liwang

AU - Lucas, Carmen M.

AU - Durand, Salomon

AU - Sanchez, Juan F.

AU - Christian Baldeviano, G.

AU - Lescano, Andres G.

AU - Laman, Moses

AU - Barnadas, Celine

AU - Barry, Alyssa

AU - Mueller, Ivo

AU - Kazura, James W.

AU - Eapen, Alex

AU - Kanagaraj, Deena

AU - Valecha, Neena

AU - Ferreira, Marcelo U.

AU - Roobsoong, Wanlapa

AU - Nguitragool, Wang

AU - Sattabonkot, Jetsumon

AU - Gamboa, Dionicia

AU - Kosek, Margaret

AU - Vinetz, Joseph M.

AU - González-Cerón, Lilia

AU - Birren, Bruce W.

AU - Neafsey, Daniel E.

AU - Carlton, Jane M.

PY - 2016/8/1

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Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

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