TY - JOUR
T1 - Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy
AU - Maheshwari, Nisha
AU - Marone, Alessandro
AU - Altoé, Mirella
AU - Kim, Stephen H.K.
AU - Bajakian, Danielle R.
AU - Hielscher, Andreas H.
N1 - Funding Information:
The authors would like to thank the patients who volunteered for this study for their time and participation. This work was supported in part by the National Heart, Lung, and Blood Institute (Grant No. NHLBI-1R01-HL115336); Wallace H. Coulter Foundation; Society of Vascular Surgery; Columbia University Fu Foundation School of Engineering and Applied Science; and New York University Tandon School of Engineering.
Publisher Copyright:
© 2022 The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Significance: Due to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention. Aim: We aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention. Approach: The DVOS used near-infrared light (670 < λ < 850 nm) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible. Results: The total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size (N = 9) and patients with ulcers that did not (N = 5) 3 to 4 weeks after intervention (p value < 0.001). Data correlated strongly (89% sensitivity, 100% specificity, and AUC . 0.96) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing. Conclusions: This pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention.
AB - Significance: Due to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention. Aim: We aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention. Approach: The DVOS used near-infrared light (670 < λ < 850 nm) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible. Results: The total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size (N = 9) and patients with ulcers that did not (N = 5) 3 to 4 weeks after intervention (p value < 0.001). Data correlated strongly (89% sensitivity, 100% specificity, and AUC . 0.96) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing. Conclusions: This pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention.
KW - dynamic optical spectroscopy
KW - near-infrared spectroscopy
KW - peripheral arterial disease
KW - revascularization
KW - wound healing
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U2 - 10.1117/1.JBO.27.12.125002
DO - 10.1117/1.JBO.27.12.125002
M3 - Article
C2 - 36582192
AN - SCOPUS:85145157408
VL - 27
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 12
M1 - 125002
ER -