TY - JOUR
T1 - Postsecretory metabolism of peptides
AU - Bunnett, N. W.
PY - 1987
Y1 - 1987
N2 - Peptide hormones and neurotransmitters play an essential role in regulation of cellular matabolism. Once released from an endocrine cell or nerve ending, peptides encounter membranebound and soluble peptidases. The peptidases inactivate peptides or form fragments with novel biologic activity. Therefore, peptidases must play a major role in homeostatic control, but this aspect of regulation has been a neglected area. This review examines the postsecretory metabolism of biologically active peptides in the brain and alimentary tract, 2 organs in which peptide regulation is of crucial importance.
AB - Peptide hormones and neurotransmitters play an essential role in regulation of cellular matabolism. Once released from an endocrine cell or nerve ending, peptides encounter membranebound and soluble peptidases. The peptidases inactivate peptides or form fragments with novel biologic activity. Therefore, peptidases must play a major role in homeostatic control, but this aspect of regulation has been a neglected area. This review examines the postsecretory metabolism of biologically active peptides in the brain and alimentary tract, 2 organs in which peptide regulation is of crucial importance.
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U2 - 10.1164/ajrccm/136.6_pt_2.s27
DO - 10.1164/ajrccm/136.6_pt_2.s27
M3 - Article
AN - SCOPUS:0023567306
VL - 136
SP - s27-s34
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
SN - 1073-449X
IS - 6 II SUPPL.
ER -