Postsynaptic effects of Aplysia cysteine-rich neurotrophic factor in the induction of activity-dependent long-term facilitation in Aplysia californica

Anamaria Alexandrescu, Thomas J. Carew

Research output: Contribution to journalArticlepeer-review

Abstract

The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of Aplysia cysteine-rich neurotrophic factor (ApCRNF) signaling during the induction of activity-dependent long-term facilitation (AD-LTF) at sensory-to-motor neuron synapses that mediate defensive reflexes in Aplysia. We found that ApCRNF signaling is required for the induction of AD-LTF, and for training-induced early protein kinase activation and late forms of gene expression, exclusively in postsynaptic neurons. These results support the view that ApCRNF is critically involved in AD-LTF at least in part through postsynaptic mechanisms.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalLearning and Memory
Volume27
Issue number4
DOIs
StatePublished - Apr 2020

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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