Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots

Farah Benyettou; Thirumurugan Prakasam; Anjana Ramdas Nair; Ini Isabee Witzel; Marwa Alhashimi; Tina Skorjanc; John Carl Olsen; Kirsten C. Sadler; Ali Trabolsi

doi:10.1039/c9sc01218d

Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots

Farah Benyettou, Thirumurugan Prakasam, Anjana Ramdas Nair, Ini Isabee Witzel, Marwa Alhashimi, Tina Skorjanc, John Carl Olsen, Kirsten C. Sadler, Ali Trabolsi

Research output: Contribution to journal › Article

Abstract

A set of metal-organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells - including those resistant to cisplatin - and in zebrafish embryos. In cultured cells, M-TKs generated reactive oxygen species that triggered apoptosis via the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development.

Original language	English (US)
Pages (from-to)	5884-5892
Number of pages	9
Journal	Chemical Science
Volume	10
Issue number	23
DOIs	https://doi.org/10.1039/c9sc01218d
State	Published - Jun 21 2019

ASJC Scopus subject areas

Chemistry(all)

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10.1039/c9sc01218d

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Benyettou, F., Prakasam, T., Ramdas Nair, A., Witzel, I. I., Alhashimi, M., Skorjanc, T., Olsen, J. C., Sadler, K. C., & Trabolsi, A. (2019). Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots. Chemical Science, 10(23), 5884-5892. https://doi.org/10.1039/c9sc01218d

Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots. / Benyettou, Farah; Prakasam, Thirumurugan; Ramdas Nair, Anjana; Witzel, Ini Isabee; Alhashimi, Marwa; Skorjanc, Tina; Olsen, John Carl; Sadler, Kirsten C.; Trabolsi, Ali.

In: Chemical Science, Vol. 10, No. 23, 21.06.2019, p. 5884-5892.

Research output: Contribution to journal › Article

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