@article{d435f80a9a4e490a9d42e416422781c0,
title = "Potent and selective in vitro and in vivo antiproliferative effects of metal-organic trefoil knots",
abstract = "A set of metal-organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells - including those resistant to cisplatin - and in zebrafish embryos. In cultured cells, M-TKs generated reactive oxygen species that triggered apoptosis via the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development.",
author = "Farah Benyettou and Thirumurugan Prakasam and {Ramdas Nair}, Anjana and Witzel, {Ini Isabee} and Marwa Alhashimi and Tina Skorjanc and Olsen, {John Carl} and Sadler, {Kirsten C.} and Ali Trabolsi",
note = "Funding Information: We thank New York University Abu Dhabi (NYUAD), UAE, for its generous support of this research, which was carried out using the Core Technology Platform resources at NYUAD. We also acknowledge the Al Jalila Foundation (AJF 201646), the New York University Abu Dhabi Research Enhancement Fund (REF AY_2017-2018), and the National Institute of Health (NIH 5R01AA018886 to KCS) for funding. The authors also thank Miss Jumaanah Alhashemi for TOC realization. Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
month = jun,
day = "21",
doi = "10.1039/c9sc01218d",
language = "English (US)",
volume = "10",
pages = "5884--5892",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "23",
}