Abstract
A set of metal-organic trefoil knots (M-TKs) generated by metal-templated self-assembly of a simple pair of chelating ligands were well tolerated in vitro by non-cancer cells but were significantly more potent than cisplatin in both human cancer cells - including those resistant to cisplatin - and in zebrafish embryos. In cultured cells, M-TKs generated reactive oxygen species that triggered apoptosis via the mitochondrial pathway without directly disrupting the cell-membrane or damaging nuclear DNA. The cytotoxicity and wide scope for structural variation of M-TKs indicate the potential of synthetic metal-organic knots as a new field of chemical space for pharmaceutical design and development.
Original language | English (US) |
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Pages (from-to) | 5884-5892 |
Number of pages | 9 |
Journal | Chemical Science |
Volume | 10 |
Issue number | 23 |
DOIs | |
State | Published - Jun 21 2019 |
ASJC Scopus subject areas
- General Chemistry