Potential contribution of naïve immune effectors to oral tumor resistance: Role in synergistic induction of VEGF, IL-6, and IL-8 secretion

Antonia Teruel, Marcela Romero, Nicholas A. Cacalano, Christian Head, Anahid Jewett

Research output: Contribution to journalArticle

Abstract

The aim of this study is to identify the phenotype of resistant oral tumors, and to delineate the contribution of immune effectors to resistance of oral tumors. UCLA-1 oral tumors which were resistant to NK cell mediated cytotoxicity secreted increased amounts of IL-6, IL-1β, GM-CSF, and IL-8 when cultured with or without immune effectors. In addition, the levels of vascular endothelial growth factor (VEGF) secretion in the co-cultures of naïve immune effectors with UCLA-1 rose significantly when compared to tumor cells alone. IL-2 activated NK cells decreased VEGF secretion in all tumor cells. However, NK cells which were induced to undergo cell death with anti-CD16 antibody were not only unable to decrease VEGF secretion, but they also contributed further to the increase in VEGF secretion by oral tumors. Overall, we show in this paper that naïve as well as non-viable immune effectors may contribute to the growth and resistance of oral tumors by triggering the secretion of key tumor cell growth factors.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalCancer Immunology, Immunotherapy
Volume57
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • IFN-γ
  • IL6
  • NK cells
  • Primary oral tumors
  • UM-SCC-1
  • VEGF

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research

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