Pulsed detonation engines can potentially revolutionize aero-space propulsion and they are the subject of intense study. However, most of the studies involve single shot and very short duration test runs. Some of the practical issues in developing PDEs are discussed from the viewpoint of developing ground-based demonstrators. This represents only the beginning of a roadmap toward the successful development of flightweight engines. Viable solutions are offered that may help overcome the difficulties posed by the high temperature and pressures on the test rig and instrumentation. Commercial solenoid valves and electronic fuel injectors are presented as means to achieving higher operational frequencies. Issues concerning data acquisition, such as proper implementing procedures for pressure transducers and choosing the appropriate sampling rates are discussed. Methods for mitigating electromagnetic interference are discussed.