Prediagnostic antibody responses to fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large U.S. Consortium

Chun Han Lo; William J. Blot; Lauren R. Teras; Kala Visvanathan; Loic Le Marchand; Christopher A. Haiman; Yu Chen; Howard D. Sesso; Sylvia Wassertheil-Smoller; Lesley F. Tinker; Richard M. Peek; John D. Potter; Timothy L. Cover; Anne Zeleniuch-Jacquotte; Sonja I. Berndt; Tim Waterboer; Meira Epplein; Julia Butt; Mingyang Song

doi:10.1158/1055-9965.EPI-20-1471

Prediagnostic antibody responses to fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large U.S. Consortium

Chun Han Lo, William J. Blot, Lauren R. Teras, Kala Visvanathan, Loic Le Marchand, Christopher A. Haiman, Yu Chen, Howard D. Sesso, Sylvia Wassertheil-Smoller, Lesley F. Tinker, Richard M. Peek, John D. Potter, Timothy L. Cover, Anne Zeleniuch-Jacquotte, Sonja I. Berndt, Tim Waterboer, Meira Epplein, Julia Butt, Mingyang Song

Urban Initiative

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Abstract

Background: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. Methods: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States. Results: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk. Conclusions: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer. Impact: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.

Original language	English (US)
Pages (from-to)	1279-1282
Number of pages	4
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	30
Issue number	6
DOIs	https://doi.org/10.1158/1055-9965.EPI-20-1471
State	Published - Jun 2021

ASJC Scopus subject areas

General Medicine

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10.1158/1055-9965.EPI-20-1471

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Lo, C. H., Blot, W. J., Teras, L. R., Visvanathan, K., Le Marchand, L., Haiman, C. A., Chen, Y., Sesso, H. D., Wassertheil-Smoller, S., Tinker, L. F., Peek, R. M., Potter, J. D., Cover, T. L., Zeleniuch-Jacquotte, A., Berndt, S. I., Waterboer, T., Epplein, M., Butt, J., & Song, M. (2021). Prediagnostic antibody responses to fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large U.S. Consortium. Cancer Epidemiology Biomarkers and Prevention, 30(6), 1279-1282. https://doi.org/10.1158/1055-9965.EPI-20-1471

Lo, CH, Blot, WJ, Teras, LR, Visvanathan, K, Le Marchand, L, Haiman, CA, Chen, Y, Sesso, HD, Wassertheil-Smoller, S, Tinker, LF, Peek, RM, Potter, JD, Cover, TL, Zeleniuch-Jacquotte, A, Berndt, SI, Waterboer, T, Epplein, M, Butt, J & Song, M 2021, 'Prediagnostic antibody responses to fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large U.S. Consortium', Cancer Epidemiology Biomarkers and Prevention, vol. 30, no. 6, pp. 1279-1282. https://doi.org/10.1158/1055-9965.EPI-20-1471

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title = "Prediagnostic antibody responses to fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large U.S. Consortium",

abstract = "Background: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. Methods: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States. Results: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk. Conclusions: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer. Impact: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.",

author = "Lo, {Chun Han} and Blot, {William J.} and Teras, {Lauren R.} and Kala Visvanathan and {Le Marchand}, Loic and Haiman, {Christopher A.} and Yu Chen and Sesso, {Howard D.} and Sylvia Wassertheil-Smoller and Tinker, {Lesley F.} and Peek, {Richard M.} and Potter, {John D.} and Cover, {Timothy L.} and Anne Zeleniuch-Jacquotte and Berndt, {Sonja I.} and Tim Waterboer and Meira Epplein and Julia Butt and Mingyang Song",

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year = "2021",

month = jun,

doi = "10.1158/1055-9965.EPI-20-1471",

language = "English (US)",

volume = "30",

pages = "1279--1282",

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T1 - Prediagnostic antibody responses to fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large U.S. Consortium

AU - Lo, Chun Han

AU - Blot, William J.

AU - Teras, Lauren R.

AU - Visvanathan, Kala

AU - Le Marchand, Loic

AU - Haiman, Christopher A.

AU - Chen, Yu

AU - Sesso, Howard D.

AU - Wassertheil-Smoller, Sylvia

AU - Tinker, Lesley F.

AU - Peek, Richard M.

AU - Potter, John D.

AU - Cover, Timothy L.

AU - Zeleniuch-Jacquotte, Anne

AU - Berndt, Sonja I.

AU - Waterboer, Tim

AU - Epplein, Meira

AU - Butt, Julia

AU - Song, Mingyang

PY - 2021/6

Y1 - 2021/6

N2 - Background: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. Methods: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States. Results: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk. Conclusions: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer. Impact: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.

AB - Background: The association between prediagnostic antibody responses to Fusobacterium nucleatum (F. nucleatum) and subsequent risk of colorectal cancer is not established. Methods: We conducted a nested case-control study of 8,126 participants in a consortium of 10 prospective cohorts in the United States. Results: Higher seroprevalence of any F. nucleatum antibody was observed among non-White participants (51.1%) compared with White participants (31.2%). We did not find any statistically significant association between seropositivity to any of the eight F. nucleatum proteins and colorectal cancer risk. Conclusions: Prediagnostic antibody responses to F. nucleatum proteins were not associated with the risk of colorectal cancer. Impact: Future studies may consider a more specific detection of the immunoglobulin isotypes or focus on examining F. nucleatum in stool or tissue samples.

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Prediagnostic antibody responses to fusobacterium nucleatum proteins are not associated with risk of colorectal cancer in a large U.S. Consortium

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