Prediction of pathologic complete response in breast cancer neoadjuvant chemotherapy based on pretreatment data obtained with dynamic diffuse optical tomography

S. Ghosh, M. L. Altoe, A. Marone, Hyun K. Kim, Kevin Kalinsky, Hua Guo, Hanina Hibshoosh, Mariella Tejada, K. Crew, M. K. Accordino, M. S. Trivedi, Dawn L. Hershman, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    In this retrospective study, we evaluated imaging data from 65 breast cancer patients that were obtained one to three days before the initiation of neoadjuvant chemotherapy (NAC). Imaging was performed with a dynamic optical tomography breast imaging system (DOTBIS) over the course of a breath hold. From this imaging data, we extracted time-dependent signal traces of the total hemoglobin in the whole volume of the tumor-bearing breast. The inflection point and the slope at the steepest part of the curve were calculated for both the ascending (patient holds her breath) and descending slopes (patient releases her breath and starts breathing normally again). Our results show statistically significant differences in vascular changes between patients with a pathologic complete response (pCR) and non-pCR patients. This suggests that differences in the tumor-bearing breasts of these two patient groups exist even before treatment is started.

    Original languageEnglish (US)
    Title of host publicationMultiscale Imaging and Spectroscopy III
    EditorsPaul J. Campagnola, Kristen C. Maitland, Darren M. Roblyer
    PublisherSPIE
    ISBN (Electronic)9781510647596
    DOIs
    StatePublished - 2022
    EventMultiscale Imaging and Spectroscopy III 2022 - Virtual, Online
    Duration: Feb 20 2022Feb 24 2022

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume11944
    ISSN (Print)1605-7422

    Conference

    ConferenceMultiscale Imaging and Spectroscopy III 2022
    CityVirtual, Online
    Period2/20/222/24/22

    Keywords

    • Diffuse optical tomography
    • neoadjuvant chemotherapy
    • pCR

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Atomic and Molecular Physics, and Optics
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

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