Predictors of altered upper extremity function during the first year after breast cancer treatment

Betty Smoot, Steven M. Paul, Bradley E. Aouizerat, Laura Dunn, Charles Elboim, Brian Schmidt, Deborah Hamolsky, Jon D. Levine, Gary Abrams, Judy Mastick, Kimberly Topp, Christine Miaskowski

Research output: Contribution to journalArticle

Abstract

Objective The purpose of this study was to evaluate trajectories of and predictors for changes in upper extremity (UE) function in women (n = 396) during the first year after breast cancer treatment. Design Prospective, longitudinal assessments of shoulder range of motion (ROM), grip strength, and perceived interference of function were performed before and for 1 year after surgery. Demographic, clinical, and treatment characteristics were evaluated as predictors of postoperative function. Results Women had a mean (SD) age of 54.9 (11.6) years, and 64% were white. Small but statistically significant reductions in shoulder ROM were found on the affected side over 12 months (P < 0.001). Predictors of interindividual differences in ROM at the 1-month assessment were ethnicity, neoadjuvant chemotherapy, type of surgery, axillary lymph node dissection, and preoperative ROM. Predictors of interindividual differences in changes over time in postoperative ROM were living alone, type of surgery, axillary lymph node dissection, and adjuvant chemotherapy. Declines in mean grip strength from before through 1 month after surgery were small and not clinically meaningful. Women with greater preoperative breast pain interference scores had higher postoperative interference scores at all postoperative assessments. Conclusion Some of the modifiable risk factors identified in this study can be targeted for intervention to improve UE function in these women.

Original languageEnglish (US)
Pages (from-to)639-655
Number of pages17
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume95
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • Breast Cancer
  • Function
  • Grip Strength
  • Mobility
  • Range of Motion
  • Upper Extremity

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Fingerprint Dive into the research topics of 'Predictors of altered upper extremity function during the first year after breast cancer treatment'. Together they form a unique fingerprint.

  • Cite this

    Smoot, B., Paul, S. M., Aouizerat, B. E., Dunn, L., Elboim, C., Schmidt, B., Hamolsky, D., Levine, J. D., Abrams, G., Mastick, J., Topp, K., & Miaskowski, C. (2016). Predictors of altered upper extremity function during the first year after breast cancer treatment. American Journal of Physical Medicine and Rehabilitation, 95(9), 639-655. https://doi.org/10.1097/PHM.0000000000000455