TY - JOUR
T1 - Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers
AU - Merriman, John D.
AU - Aouizerat, Bradley E.
AU - Langford, Dale J.
AU - Cooper, Bruce A.
AU - Baggott, Christina R.
AU - Cataldo, Janine K.
AU - Dhruva, Anand
AU - Dunn, Laura
AU - West, Claudia
AU - Paul, Steven M.
AU - Ritchie, Christine S.
AU - Swift, Patrick S.
AU - Miaskowski, Christine
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by a National Institute of Nursing Research (NINR) R01 grant (NR04835). Mr. Merriman is supported by an NINR F31 National Research Service Award (NR012604); an American Cancer Society (ACS) Doctoral Degree Scholarship in Cancer Nursing (DSCNR-10-087); an Oncology Nursing Society (ONS) Foundation Doctoral Scholarship; and a University of California, San Francisco (UCSF), Nursing Alumni Association Scholarship. Dr. Aouizerat was funded through a National Institutes of Health (NIH) Roadmap for Medical Research Grant (KL2 RR624130). Drs. Dunn and Aouizerat are partially supported by a UCSF Academic Senate grant. Dr. Langford is supported by a Breast Cancer Research Program Department of Defense Postdoctoral Fellowship. Dr. Baggott is supported by an ACS Mentored Research Scholar Grant (MRSG-12-01-PCSM). Dr. Cataldo is partially supported by an ONS Genetic Fellowship Award. Dr. Dhruva is funded through an NIH Mentored Patient-Oriented Research Career Development Award (K23 AT005340). Dr. Ritchie is funded through an NIH Geriatric Academic Leadership Award (1K07AG31779) and the Harris Fishbon Professorship for Clinical Translational Research in Aging. Dr. Miaskowski is funded by the ACS as a Clinical Research Professor.
PY - 2014/4
Y1 - 2014/4
N2 - Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.
AB - Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.
KW - attention
KW - cancer
KW - cytokines
KW - genetic association studies
KW - inflammation
KW - radiotherapy
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U2 - 10.1177/1099800413479441
DO - 10.1177/1099800413479441
M3 - Article
C2 - 23482714
AN - SCOPUS:84894519801
SN - 1099-8004
VL - 16
SP - 152
EP - 159
JO - Biological Research for Nursing
JF - Biological Research for Nursing
IS - 2
ER -