Prenatal cocaine decreases the trophic factor S-100β and induced microcephaly: Reversal by postnatal 5-HT1A receptor agonist

Homayoon M. Akbari, Patricia M. Whitaker-Azmitia, Efrain C. Azmitia

Research output: Contribution to journalArticlepeer-review

Abstract

In utero exposure to cocaine results in neurobehavioral abnormalities in both clinical and laboratory studies. Cocaine administration from embryonic day 13 to parturition disrupts the distribution of S-100-positive astrocytes in the hippocampus and subplate region of the cortex in cocaine-exposed animals. Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalNeuroscience letters
Volume170
Issue number1
DOIs
StatePublished - Mar 28 1994

Keywords

  • Astrocyte
  • Cocaine
  • Ipsapirone
  • Microcephaly
  • Neurodevelopment
  • S-100
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)

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