Abstract
In utero exposure to cocaine results in neurobehavioral abnormalities in both clinical and laboratory studies. Cocaine administration from embryonic day 13 to parturition disrupts the distribution of S-100-positive astrocytes in the hippocampus and subplate region of the cortex in cocaine-exposed animals. Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure.
Original language | English (US) |
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Pages (from-to) | 141-144 |
Number of pages | 4 |
Journal | Neuroscience letters |
Volume | 170 |
Issue number | 1 |
DOIs | |
State | Published - Mar 28 1994 |
Keywords
- Astrocyte
- Cocaine
- Ipsapirone
- Microcephaly
- Neurodevelopment
- S-100
- Serotonin
ASJC Scopus subject areas
- Neuroscience(all)