Prenatal cocaine decreases the trophic factor S-100 beta and induced microcephaly: reversal by postnatal 5-HT1A receptor agonist

H. M. Akbari; P. M. Whitaker-Azmitia; E. C. Azmitia

Prenatal cocaine decreases the trophic factor S-100 beta and induced microcephaly: reversal by postnatal 5-HT1A receptor agonist

H. M. Akbari, P. M. Whitaker-Azmitia, E. C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

In utero exposure to cocaine results in neurobehavioral abnormalities in both clinical and laboratory studies. Cocaine administration from embryonic day 13 to parturition disrupts the distribution of S-100-positive astrocytes in the hippocampus and subplate region of the cortex in cocaine-exposed animals. Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure.

Original language	Undefined
Pages (from-to)	141-4
Journal	Neuroscience Letters
Volume	170
Issue number	1
State	Published - 1994

Keywords

Animals Astrocytes/drug effects/metabolism Cerebral Cortex/cytology/drug effects/metabolism Cocaine/*antagonists & inhibitors/toxicity Female Hippocampus/cytology/drug effects/metabolism Immunohistochemistry Microcephaly/chemically induced/*prevention & control Pregnancy Prenatal Exposure Delayed Effects Pyrimidines/pharmacology Rats Rats, Sprague-Dawley S100 Proteins/immunology/*metabolism Serotonin Antagonists/pharmacology Serotonin Receptor Agonists/*pharmacology

Cite this

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title = "Prenatal cocaine decreases the trophic factor S-100 beta and induced microcephaly: reversal by postnatal 5-HT1A receptor agonist",

abstract = "In utero exposure to cocaine results in neurobehavioral abnormalities in both clinical and laboratory studies. Cocaine administration from embryonic day 13 to parturition disrupts the distribution of S-100-positive astrocytes in the hippocampus and subplate region of the cortex in cocaine-exposed animals. Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure.",

keywords = "Animals Astrocytes/drug effects/metabolism Cerebral Cortex/cytology/drug effects/metabolism Cocaine/*antagonists & inhibitors/toxicity Female Hippocampus/cytology/drug effects/metabolism Immunohistochemistry Microcephaly/chemically induced/*prevention & control Pregnancy Prenatal Exposure Delayed Effects Pyrimidines/pharmacology Rats Rats, Sprague-Dawley S100 Proteins/immunology/*metabolism Serotonin Antagonists/pharmacology Serotonin Receptor Agonists/*pharmacology",

author = "Akbari, {H. M.} and Whitaker-Azmitia, {P. M.} and Azmitia, {E. C.}",

note = "Akbari, H M Whitaker-Azmitia, P M Azmitia, E C Journal Article Ireland Neurosci Lett. 1994 Mar 28;170(1):141-4.",

year = "1994",

language = "Undefined",

volume = "170",

pages = "141--4",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

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TY - JOUR

T1 - Prenatal cocaine decreases the trophic factor S-100 beta and induced microcephaly: reversal by postnatal 5-HT1A receptor agonist

AU - Akbari, H. M.

AU - Whitaker-Azmitia, P. M.

AU - Azmitia, E. C.

N1 - Akbari, H M Whitaker-Azmitia, P M Azmitia, E C Journal Article Ireland Neurosci Lett. 1994 Mar 28;170(1):141-4.

PY - 1994

Y1 - 1994

N2 - In utero exposure to cocaine results in neurobehavioral abnormalities in both clinical and laboratory studies. Cocaine administration from embryonic day 13 to parturition disrupts the distribution of S-100-positive astrocytes in the hippocampus and subplate region of the cortex in cocaine-exposed animals. Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure.

AB - In utero exposure to cocaine results in neurobehavioral abnormalities in both clinical and laboratory studies. Cocaine administration from embryonic day 13 to parturition disrupts the distribution of S-100-positive astrocytes in the hippocampus and subplate region of the cortex in cocaine-exposed animals. Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure.

KW - Animals Astrocytes/drug effects/metabolism Cerebral Cortex/cytology/drug effects/metabolism Cocaine/antagonists & inhibitors/toxicity Female Hippocampus/cytology/drug effects/metabolism Immunohistochemistry Microcephaly/chemically induced/prevention & con

M3 - Article

SN - 0304-3940

VL - 170

SP - 141

EP - 144

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -