Prenatal Mild Ventriculomegaly Predicts Abnormal Development of the Neonatal Brain

John H. Gilmore, Lauren C. Smith, Honor M. Wolfe, Barbara S. Hertzberg, J. Keith Smith, Nancy C. Chescheir, Dianne D. Evans, Chaeryon Kang, Robert M. Hamer, Weili Lin, Guido Gerig

Research output: Contribution to journalArticlepeer-review


Background: Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development. Methods: We performed neonatal magnetic resonance imaging on 34 children with isolated mild ventriculomegaly (MVM; width of the atrium of the lateral ventricle ≥ 1.0 cm) on prenatal ultrasound and 34 age- and sex-matched control subjects with normal prenatal ventricle size. Lateral ventricle and cortical gray and white matter volumes were assessed. Fractional anisotropy (FA) and mean diffusivity (MD) in corpus callosum and corticospinal white matter tracts were determined obtained using quantitative tractography. Results: Neonates with prenatal MVM had significantly larger lateral ventricle volumes than matched control subjects (286.4%; p < .0001). Neonates with MVM also had significantly larger intracranial volumes (ICV; 7.1%, p = .0063) and cortical gray matter volumes (10.9%, p = .0004) compared with control subjects. Diffusion tensor imaging tractography revealed a significantly greater MD in the corpus callosum and corticospinal tracts, whereas FA was significantly smaller in several white matter tract regions. Conclusions: Prenatal enlargement of the lateral ventricle is associated with enlargement of the lateral ventricles after birth, as well as greater gray matter volumes and delayed or abnormal maturation of white matter. It is suggested that prenatal ventricle volume is an early structural marker of altered development of the cerebral cortex and may be a marker of risk for neuropsychiatric disorders associated with ventricle enlargement.

Original languageEnglish (US)
Pages (from-to)1069-1076
Number of pages8
JournalBiological Psychiatry
Issue number12
StatePublished - Dec 15 2008


  • Autism
  • cortex
  • diffusion tensor imaging
  • lateral ventricle
  • magnetic resonance imaging
  • schizophrenia
  • ultrasound

ASJC Scopus subject areas

  • Biological Psychiatry


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