Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones

Armando P. Ramirez; Andrew M. Thomas; K. A. Woerpel

doi:10.1021/ol8022853

Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones

Armando P. Ramirez, Andrew M. Thomas, K. A. Woerpel

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Treatment of γ,δ-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.

Original language	English (US)
Pages (from-to)	507-510
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1021/ol8022853
State	Published - Feb 5 2009

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol8022853

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title = "Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones",

abstract = "(Chemical Equation Presented) Treatment of γ,δ-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.",

author = "Ramirez, {Armando P.} and Thomas, {Andrew M.} and Woerpel, {K. A.}",

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AU - Thomas, Andrew M.

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AB - (Chemical Equation Presented) Treatment of γ,δ-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.

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Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones

Abstract

ASJC Scopus subject areas

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