Preparation of bicyclic 1,2,4-trioxanes from γ,δ-unsaturated ketones

Armando P. Ramirez, Andrew M. Thomas, K. A. Woerpel

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) Treatment of γ,δ-unsaturated ketones with hydrogen peroxide and acid provides a rapid entry into the medicinally important 1,2,4-trioxane structure. Alkene substitution that stabilizes carbocationic intermediates proved to be important for the success of this transformation.

Original languageEnglish (US)
Pages (from-to)507-510
Number of pages4
JournalOrganic Letters
Issue number3
StatePublished - Feb 5 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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