TY - JOUR
T1 - Preparation of narrow-distribution polyvinylpyrrolidone by multi-stage high osmotic pressure chromatography
AU - Xu, Y.
AU - Teraoka, I.
AU - Senak, L.
AU - Wu, C. S.
N1 - Funding Information:
The present work was supported by NSF through a Grant No. DMR 9458055. We also thank Erika Teraoka for assistance in separation.
PY - 1999/12
Y1 - 1999/12
N2 - Separation of polyvinylpyrrolidone, a water-soluble polymer of neutral charge, by high osmotic pressure chromatography (HOPC) is presented. HOPC, suitable for preparative separation of polymer by molecular weight, has been applied to various organic-soluble polymers. We demonstrate here that HOPC can also separate water-soluble polymers and is capable of separating fractions of narrower polydispersity compared to preparative gel permeation chromatography (GPC). Typically fractions with a polydispersity index (PDI) of 1.4-2 were generated from broad-distribution polymers (PDI to approximately 5) in significant quantities from a single separation. By multi-stage separation, standard-grade fractions were obtained. Single- and multi-pass fractions were characterized by both GPC with narrow-standard calibration and GPC in tandem with a multi-angle laser light scattering detector.
AB - Separation of polyvinylpyrrolidone, a water-soluble polymer of neutral charge, by high osmotic pressure chromatography (HOPC) is presented. HOPC, suitable for preparative separation of polymer by molecular weight, has been applied to various organic-soluble polymers. We demonstrate here that HOPC can also separate water-soluble polymers and is capable of separating fractions of narrower polydispersity compared to preparative gel permeation chromatography (GPC). Typically fractions with a polydispersity index (PDI) of 1.4-2 were generated from broad-distribution polymers (PDI to approximately 5) in significant quantities from a single separation. By multi-stage separation, standard-grade fractions were obtained. Single- and multi-pass fractions were characterized by both GPC with narrow-standard calibration and GPC in tandem with a multi-angle laser light scattering detector.
KW - High osmotic pressure chromatography
KW - Multi-angle light scattering detector
KW - Polyvinylpyrrolidone
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U2 - 10.1016/S0032-3861(99)00080-4
DO - 10.1016/S0032-3861(99)00080-4
M3 - Article
AN - SCOPUS:0344603842
SN - 0032-3861
VL - 40
SP - 7359
EP - 7366
JO - Polymer
JF - Polymer
IS - 26
ER -