Preparation of narrow-distribution polyvinylpyrrolidone by multi-stage high osmotic pressure chromatography

Y. Xu, I. Teraoka, L. Senak, C. S. Wu

Research output: Contribution to journalArticlepeer-review


Separation of polyvinylpyrrolidone, a water-soluble polymer of neutral charge, by high osmotic pressure chromatography (HOPC) is presented. HOPC, suitable for preparative separation of polymer by molecular weight, has been applied to various organic-soluble polymers. We demonstrate here that HOPC can also separate water-soluble polymers and is capable of separating fractions of narrower polydispersity compared to preparative gel permeation chromatography (GPC). Typically fractions with a polydispersity index (PDI) of 1.4-2 were generated from broad-distribution polymers (PDI to approximately 5) in significant quantities from a single separation. By multi-stage separation, standard-grade fractions were obtained. Single- and multi-pass fractions were characterized by both GPC with narrow-standard calibration and GPC in tandem with a multi-angle laser light scattering detector.

Original languageEnglish (US)
Pages (from-to)7359-7366
Number of pages8
Issue number26
StatePublished - Dec 1999


  • High osmotic pressure chromatography
  • Multi-angle light scattering detector
  • Polyvinylpyrrolidone

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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