Presynaptic Protein Synthesis in Brain Function and Disease

Pablo E. Castillo, Hosung Jung, Eric Klann, Antonella Riccio

Research output: Contribution to journalArticlepeer-review


Local protein synthesis in mature brain axons regulates the structure and function of presynaptic boutons by adjusting the presynaptic proteome to local demands. This crucial mechanism underlies experience-dependent modifications of brain circuits, and its dysregulation may contribute to brain disorders, such as autism and intellectual disability. Here, we discuss recent advancements in the axonal transcriptome, axonal RNA localization and translation, and the role of presynaptic local translation in synaptic plasticity and memory.

Original languageEnglish (US)
Pages (from-to)7483-7488
Number of pages6
JournalJournal of Neuroscience
Issue number45
StatePublished - Nov 8 2023

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Presynaptic Protein Synthesis in Brain Function and Disease'. Together they form a unique fingerprint.

Cite this