Presynaptic Protein Synthesis in Brain Function and Disease

Pablo E. Castillo; Hosung Jung; Eric Klann; Antonella Riccio

doi:10.1523/JNEUROSCI.1454-23.2023

Presynaptic Protein Synthesis in Brain Function and Disease

Pablo E. Castillo, Hosung Jung, Eric Klann, Antonella Riccio

Neural Science

Research output: Contribution to journal › Article › peer-review

Abstract

Local protein synthesis in mature brain axons regulates the structure and function of presynaptic boutons by adjusting the presynaptic proteome to local demands. This crucial mechanism underlies experience-dependent modifications of brain circuits, and its dysregulation may contribute to brain disorders, such as autism and intellectual disability. Here, we discuss recent advancements in the axonal transcriptome, axonal RNA localization and translation, and the role of presynaptic local translation in synaptic plasticity and memory.

Original language	English (US)
Pages (from-to)	7483-7488
Number of pages	6
Journal	Journal of Neuroscience
Volume	43
Issue number	45
DOIs	https://doi.org/10.1523/JNEUROSCI.1454-23.2023
State	Published - Nov 8 2023

ASJC Scopus subject areas

General Neuroscience

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10.1523/JNEUROSCI.1454-23.2023

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Presynaptic Protein Synthesis in Brain Function and Disease

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