Prevalence and Incidence of Mild Cognitive Impairment in Adults with Diabetes in the United States

Yaguang Zheng, Qianheng Ma, Xiang Qi, Zheng Zhu, Bei Wu

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Limited evidence exists about the prevalence and incidence of mild cognitive impairment (MCI) in individuals with diabetes in the U.S. We aimed to address such knowledge gaps using a nationally representative study dataset.

METHOD: We conducted a secondary analysis from the Health and Retirement Study (HRS) (1996-2018). The sample for examining the prevalence of MCI was14,988, with 4,192 (28.0%) having diabetes, while the sample for the incidence was 21,824, with 1,534 (28.0%) having diabetes.

RESULTS: Participants with diabetes had a higher prevalence of MCI than those without diabetes (19.9% vs. 14.8%; odds ratio [95% confidence interval] (OR[95%CI]): 1.468 [1.337, 1.611], p<.001). The incidence of MCI in participants with/without newly diagnosed diabetes was 42.9% vs. 31.6% after a mean 10-year follow-up, with the incidence rate ratio (IRR) [95%CI] (1.314 [1.213, 1.424], p<.001). Newly diagnosed diabetes was associated with elevated risks of MCI compared with non-diabetes, with the uncontrolled hazard ratio (HR) [95%CI] (1.498 [1.405, 1.597], p<.001).

CONCLUSIONS: Using a nationally representative study data in the U.S., participants with diabetes had a higher prevalence and incidence of MCI than those without diabetes. Findings show the importance of developing interventions tailored to the needs of individuals with diabetes and cognitive impairment.

Original languageEnglish (US)
Article number110976
Pages (from-to)110976
JournalDiabetes Research and Clinical Practice
Volume205
Early online dateOct 25 2023
DOIs
StatePublished - Nov 2023

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