Prevention of ECS-induced amnesia by reestablishing continuity with the training situation

Efrain C. Azmitia, Bruce S. McEwen, David Quartermain

Research output: Contribution to journalArticle

Abstract

Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
JournalPhysiology and Behavior
Volume8
Issue number5
DOIs
StatePublished - May 1972

Keywords

  • ECS
  • Passive avoidance
  • Retrograde amnesia

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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