Prevention of ECS-induced amnesia by reestablishing continuity with the training situation

Efrain C. Azmitia; Bruce S. McEwen; David Quartermain

doi:10.1016/0031-9384(72)90296-X

Prevention of ECS-induced amnesia by reestablishing continuity with the training situation

Efrain C. Azmitia, Bruce S. McEwen, David Quartermain

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.

Original language	English (US)
Pages (from-to)	853-855
Number of pages	3
Journal	Physiology and Behavior
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/0031-9384(72)90296-X
State	Published - May 1972

Keywords

ECS
Passive avoidance
Retrograde amnesia

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(72)90296-X

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title = "Prevention of ECS-induced amnesia by reestablishing continuity with the training situation",

abstract = "Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.",

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T1 - Prevention of ECS-induced amnesia by reestablishing continuity with the training situation

AU - Azmitia, Efrain C.

AU - McEwen, Bruce S.

AU - Quartermain, David

PY - 1972/5

Y1 - 1972/5

N2 - Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.

AB - Retrograde amnesia for a passive avoidance task was produced in rats by electroconvulsive shock (ECS). However, if rats were left to recover for 15 min in the training apparatus after receiving a foot shock-ECS combination, they showed no sign of amnesia at testing 24-hr later. ECS alone without training had no effect on the step-out latencies. Amnesia did occur when the place of training was different from the place of recovery. The results suggest that a core memory survives ECS treatment and that this surviving trace is retrievable at the retest trial if continuity with the preceding experimental events is established upon recovery from the black-out produced by ECS.

KW - ECS

KW - Passive avoidance

KW - Retrograde amnesia

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Prevention of ECS-induced amnesia by reestablishing continuity with the training situation

Abstract

Keywords

ASJC Scopus subject areas

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