Primary auditory cortex regulates threat memory specificity

Mattis B. Wigestrand, Hillary C. Schiff, Marianne Fyhn, Joseph E. LeDoux, Robert M. Sears

Research output: Contribution to journalArticlepeer-review


Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used muscimol infusions in rats to show that discriminatory threat learning requires Au1 activity specifically during memory acquisition and retrieval, but not during consolidation. Memory specificity was similarly disrupted by infusion of PKMz inhibitor peptide (ZIP) during memory storage. Our findings show that Au1 is required at critical memory phases and suggest that Au1 plasticity enables stimulus discrimination.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalLearning and Memory
Issue number1
StatePublished - Jan 2017

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


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