Primer preactivation of peptidoglycan polymerases

Tsung Shing Andrew Wang; Tania J. Lupoli; Yuto Sumida; Hirokazu Tsukamoto; Yihui Wu; Yuriy Rebets; Daniel E. Kahne; Suzanne Walker

doi:10.1021/ja2028712

Primer preactivation of peptidoglycan polymerases

Tsung Shing Andrew Wang, Tania J. Lupoli, Yuto Sumida, Hirokazu Tsukamoto, Yihui Wu, Yuriy Rebets, Daniel E. Kahne, Suzanne Walker

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.

Original language	English (US)
Pages (from-to)	8528-8530
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	133
Issue number	22
DOIs	https://doi.org/10.1021/ja2028712
State	Published - Jun 8 2011

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja2028712

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abstract = "Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.",

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AU - Wang, Tsung Shing Andrew

AU - Lupoli, Tania J.

AU - Sumida, Yuto

AU - Tsukamoto, Hirokazu

AU - Wu, Yihui

AU - Rebets, Yuriy

AU - Kahne, Daniel E.

AU - Walker, Suzanne

PY - 2011/6/8

Y1 - 2011/6/8

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AB - Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.

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JF - Journal of the American Chemical Society

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Primer preactivation of peptidoglycan polymerases

Abstract

ASJC Scopus subject areas

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