Primer preactivation of peptidoglycan polymerases

Tsung Shing Andrew Wang, Tania J. Lupoli, Yuto Sumida, Hirokazu Tsukamoto, Yihui Wu, Yuriy Rebets, Daniel E. Kahne, Suzanne Walker

Research output: Contribution to journalArticlepeer-review

Abstract

Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.

Original languageEnglish (US)
Pages (from-to)8528-8530
Number of pages3
JournalJournal of the American Chemical Society
Volume133
Issue number22
DOIs
StatePublished - Jun 8 2011

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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