@article{f3cbb264bf5b4945a3eecf4e39adabe0,
title = "Problems with using polygenic scores to select embryos",
abstract = "Companies have recently begun to sell a new service to patients considering in vitro fertilization: embryo selection based on polygenic scores (ESPS). These scores represent individualized predictions of health and other outcomes derived from genomewide association studies in adults to partially predict these outcomes. This article includes a discussion of many factors that lower the predictive power of polygenic scores in the context of embryo selection and quantifies these effects for a variety of clinical and nonclinical traits. Also discussed are potential unintended consequences of ESPS (including selecting for adverse traits, altering population demographics, exacerbating inequalities in society, and devaluing certain traits). Recommendations for the responsible communication about ESPS by practitioners are provided, and a call for a society-wide conversation about this technology is made. (Funded by the National Institute on Aging and others.).",
author = "Patrick Turley and Meyer, {Michelle N.} and Nancy Wang and David Cesarini and Evelynn Hammonds and Martin, {Alicia R.} and Neale, {Benjamin M.} and Rehm, {Heidi L.} and Louise Wilkins-Haug and Benjamin, {Daniel J.} and Steven Hyman and David Laibson and Visscher, {Peter M.}",
note = "Funding Information: Supported by grants from the National Institute on Aging (R01AG042568-04 and R24AG065184) to Drs. Benjamin, Cesa- rini, Laibson, Meyer, Turley, and Visscher; a grant from Open Philanthropy (010623-00001) to Drs. Benjamin, Cesarini, Meyer, and Turley; a grant from the Ragnar S{\"o}derberg Foundation (E42/15) to Drs. Benjamin and Cesarini; funds from the Pershing Square Fund for Research on the Foundations of Human Behavior to Dr. Laibson; funds from the Stanley Family Foundation to Drs. Martin, Neale, and Hyman; a grant from the National Institute of Mental Health (K99MH117229) to Dr. Martin; a grant from the National Institute on Aging (R00AG062787-03) to Dr. Turley; grants from the Robert Wood Johnson Foundation (76565) and from the Russell Sage Foundation and the JPB Foundation (1903-13498) to Dr. Meyer; and grants from the National Health and Medical Research Council (1113400) and the Australian Research Council (FL180100072) to Dr. Visscher. Publisher Copyright: Copyright {\textcopyright} 2021 Massachusetts Medical Society.",
year = "2021",
month = jul,
day = "1",
doi = "10.1056/NEJMsr2105065",
language = "English (US)",
volume = "385",
pages = "78--86",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "1",
}