Problems With Using Polygenic Scores to Select Embryos

Patrick Turley; Michelle N. Meyer; Nancy Wang; David Cesarini; Evelynn Hammonds; Alicia R. Martin; Benjamin M. Neale; Heidi L. Rehm; Louise Wilkins-Haug; Daniel J. Benjamin; Steven Hyman; David Laibson; Peter M. Visscher

doi:10.1097/OGX.0000000000000972

Problems With Using Polygenic Scores to Select Embryos

Patrick Turley, Michelle N. Meyer, Nancy Wang, David Cesarini, Evelynn Hammonds, Alicia R. Martin, Benjamin M. Neale, Heidi L. Rehm, Louise Wilkins-Haug, Daniel J. Benjamin, Steven Hyman, David Laibson, Peter M. Visscher

Research output: Contribution to journal › Article › peer-review

Abstract

Embryo selection based on polygenic scores (ESPS) is the principle wherein one can select individualized embryos to transfer as part of in vitro fertilization based on predictions of health and other outcomes derived from genome-wide association studies (GWASs). The majority of human traits including physical characteristics and risk for disease are influenced by cumulative differences in genetic variants.

Original language	English (US)
Pages (from-to)	609-610
Number of pages	2
Journal	Obstetrical and Gynecological Survey
Volume	76
Issue number	10
DOIs	https://doi.org/10.1097/OGX.0000000000000972
State	Published - Oct 1 2021

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1097/OGX.0000000000000972

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title = "Problems With Using Polygenic Scores to Select Embryos",

abstract = "Embryo selection based on polygenic scores (ESPS) is the principle wherein one can select individualized embryos to transfer as part of in vitro fertilization based on predictions of health and other outcomes derived from genome-wide association studies (GWASs). The majority of human traits including physical characteristics and risk for disease are influenced by cumulative differences in genetic variants.",

author = "Patrick Turley and Meyer, {Michelle N.} and Nancy Wang and David Cesarini and Evelynn Hammonds and Martin, {Alicia R.} and Neale, {Benjamin M.} and Rehm, {Heidi L.} and Louise Wilkins-Haug and Benjamin, {Daniel J.} and Steven Hyman and David Laibson and Visscher, {Peter M.}",

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AU - Turley, Patrick

AU - Meyer, Michelle N.

AU - Wang, Nancy

AU - Cesarini, David

AU - Hammonds, Evelynn

AU - Martin, Alicia R.

AU - Neale, Benjamin M.

AU - Rehm, Heidi L.

AU - Wilkins-Haug, Louise

AU - Benjamin, Daniel J.

AU - Hyman, Steven

AU - Laibson, David

AU - Visscher, Peter M.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Embryo selection based on polygenic scores (ESPS) is the principle wherein one can select individualized embryos to transfer as part of in vitro fertilization based on predictions of health and other outcomes derived from genome-wide association studies (GWASs). The majority of human traits including physical characteristics and risk for disease are influenced by cumulative differences in genetic variants.

AB - Embryo selection based on polygenic scores (ESPS) is the principle wherein one can select individualized embryos to transfer as part of in vitro fertilization based on predictions of health and other outcomes derived from genome-wide association studies (GWASs). The majority of human traits including physical characteristics and risk for disease are influenced by cumulative differences in genetic variants.

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JO - Obstetrical and Gynecological Survey

JF - Obstetrical and Gynecological Survey

IS - 10

ER -

Problems With Using Polygenic Scores to Select Embryos

Abstract

ASJC Scopus subject areas

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