Processing asymmetry of transitions between order and disorder in human auditory cortex

Maria Chait, David Poeppel, Alain De Cheveigné, Jonathan Z. Simon

Research output: Contribution to journalArticle

Abstract

Auditory environments vary as a result of the appearance and disappearance of acoustic sources, as well as fluctuations characteristic of the sources themselves. The appearance of an object is often manifest as a transition in the pattern of ongoing fluctuation, rather than an onset or offset of acoustic power. How does the system detect and process such transitions? Based on magnetoencephalography data, we show that the temporal dynamics and response morphology of the neural temporal-edge detection processes depend in precise ways on the nature of the change. We measure auditory cortical responses to transitions between "disorder," modeled as a sequence of random frequency tone pips, and "order," modeled as a constant tone. Such transitions embody key characteristics of natural auditory edges. Early cortical responses (from ∼50 ms post-transition) reveal that order-disorder transitions, and vice versa, are processed by different neural mechanisms. Their dynamics suggest that the auditory cortex optimally adjusts to stimulus statistics, even when this is not required for overt behavior. Furthermore, this response profile bears a striking similarity to that measured from another order-disorder transition, between interaurally correlated and uncorrelated noise, a radically different stimulus. This parallelism suggests the existence of a general mechanism that operates early in the processing stream on the abstract statistics of the auditory input, and is putatively related to the processes of constructing a new representation or detecting a deviation from a previously acquired model of the auditory scene. Together, the data reveal information about the mechanisms with which the brain samples, represents, and detects changes in the environment.

Original languageEnglish (US)
Pages (from-to)5207-5214
Number of pages8
JournalJournal of Neuroscience
Volume27
Issue number19
DOIs
StatePublished - May 9 2007

Keywords

  • Auditory cortex
  • Auditory evoked response
  • Change detection
  • Integration window
  • M100
  • M50
  • MMN
  • Magnetoencephalography
  • Scene analysis

ASJC Scopus subject areas

  • Neuroscience(all)

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