Profiling breast cancer by array CGH

Donna G. Albertson

doi:10.1023/A:1023025506386

Profiling breast cancer by array CGH

Donna G. Albertson

Oral and Maxillofacial Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.

Original language	English (US)
Pages (from-to)	289-298
Number of pages	10
Journal	Breast Cancer Research and Treatment
Volume	78
Issue number	3
DOIs	https://doi.org/10.1023/A:1023025506386
State	Published - Apr 2003

Keywords

Array CGH
Copy number aberration
Genome instability

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1023/A:1023025506386

Cite this

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title = "Profiling breast cancer by array CGH",

abstract = "Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.",

keywords = "Array CGH, Copy number aberration, Genome instability",

author = "Albertson, {Donna G.}",

note = "Funding Information: This work was supported by NIH grants CA80314, CA83040, CA84118, HD17665 and CA58207 by California BCRP grant 2RB-0225 and Vysis, Inc.",

year = "2003",

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doi = "10.1023/A:1023025506386",

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N1 - Funding Information: This work was supported by NIH grants CA80314, CA83040, CA84118, HD17665 and CA58207 by California BCRP grant 2RB-0225 and Vysis, Inc.

PY - 2003/4

Y1 - 2003/4

N2 - Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.

AB - Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.

KW - Array CGH

KW - Copy number aberration

KW - Genome instability

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JF - Breast Cancer Research and Treatment

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Profiling breast cancer by array CGH

Abstract

Keywords

ASJC Scopus subject areas

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