Profiling breast cancer by array CGH

Research output: Contribution to journalReview article

Abstract

Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.

Original languageEnglish (US)
Pages (from-to)289-298
Number of pages10
JournalBreast Cancer Research and Treatment
Volume78
Issue number3
DOIs
StatePublished - Apr 2003

Keywords

  • Array CGH
  • Copy number aberration
  • Genome instability

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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