Programing the formation of DNA and PNA quadruplexes by π-π-stacking interactions

Sourav Saha, Jianfeng Cai, Daniel Eiler, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review


Guanine (G) rich G4T4G4 DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5′-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by π-π-stacking interaction exerted by the 5′-residues.

Original languageEnglish (US)
Pages (from-to)1685-1687
Number of pages3
JournalChemical Communications
Issue number10
StatePublished - 2010

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • General Chemistry
  • Catalysis


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