Programmable bio-nanochip technology for the diagnosis of cardiovascular disease at the point-of-care.

Nicolaos Christodoulides, Floriano N. Pierre, Ximena Sanchez, Luanyi Li, Kyle Hocquard, Aaron Patton, Rachna Muldoon, Craig S. Miller, Jeffrey L. Ebersole, Spencer Redding, Chih Ko Yeh, Wieslaw B. Furmaga, David A. Wampler, Biykem Bozkurt, Christie M. Ballantyne, John T. McDevitt

Research output: Contribution to journalReview articlepeer-review


Cardiovascular disease remains the leading cause of death in the world and continues to serve as the major contributor to healthcare costs. Likewise, there is an ever-increasing need and demand for novel and more efficient diagnostic tools for the early detection of cardiovascular disease, especially at the point-of-care (POC). This article reviews the programmable bio-nanochip (P-BNC) system, a new medical microdevice approach with the capacity to deliver both high performance and reduced cost. This fully integrated, total analysis system leverages microelectronic components, microfabrication techniques, and nanotechnology to noninvasively measure multiple cardiac biomarkers in complex fluids, such as saliva, while offering diagnostic accuracy equal to laboratory-confined reference methods. This article profiles the P-BNC approach, describes its performance in real-world testing of clinical samples, and summarizes new opportunities for medical microdevices in the field of cardiac diagnostics.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalMethodist DeBakey cardiovascular journal
Issue number1
StatePublished - Jan 2012

ASJC Scopus subject areas

  • General Medicine


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